Seven-year clinical outcomes after collagenase injection in patients with Dupuytren's disease: A prospective study: Journal of Orthopaedics

R. De Vitis, M. Passiatore, A. Perna, S. Careri, V. Cilli, G. Taccardo

Research output: Contribution to journalArticlepeer-review

Abstract

Introduction: This investigation is a prospective cohort study examining the use of Clostridium histolyticum collagenase injection (CCH) for the treatment of Dupuytren's disease (DD) with a 7 years follow-up. Methods: Forty-five monodigital DD patients were injected with CCH on a single joint. Assessment included measurement of residual passive extension deficit (PED), function (using QuickDASH) and patient satisfaction. Results: 86.7% of PIPJ and 65.6% of MPJ had a worsening of PED. Nevertheless, thirty-nine patients (86.7%) concluded their treatment with only one injection, without any further treatment. Conclusion: CCH provides a long-term effective solution. Recurrence occurs, especially in PIPJ, with acceptable rates. © 2020 Professor P K Surendran Memorial Education Foundation
Original languageEnglish
Pages (from-to)218-222
Number of pages5
JournalJ. Orthop.
Volume21
DOIs
Publication statusPublished - 2020

Keywords

  • Collagenase injection
  • Dupuytren
  • Hand function
  • Recurrence rate
  • Seven years
  • collagenase
  • aged
  • Article
  • clinical article
  • clinical outcome
  • Clostridium histolyticum
  • cohort analysis
  • controlled study
  • Disabilities of the Arm, Shoulder and Hand (score)
  • drug efficacy
  • drug safety
  • Dupuytren contracture
  • ecchymosis
  • edema
  • female
  • follow up
  • human
  • lymphadenitis
  • male
  • metacarpophalangeal joint
  • multicenter study
  • observational study
  • patient satisfaction
  • priority journal
  • prospective study
  • proximal interphalangeal joint
  • QuickDASH
  • recurrence risk
  • skin defect
  • swelling

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