Seventeen years of experience with ATRA-based therapy for acute promyelocytic leukaemia: Long-term follow-up of patients treated at S. Martino Hospital, Genoa

Marino Clavio, Anna Ghiso, Chiara Ghiggi, Mauro Spriano, Nicoletta Colombo, Raffaella Grasso, Riccardo Varaldo, Maurizio Miglino, Ivana Pierri, Francesco Olcese, Sara Aquino, Samantha Biasco, Enrico Balleari, Angelo Michele Carella, Mario Sessarego, Marco Gobbi

Research output: Contribution to journalArticlepeer-review

Abstract

We conducted a long-term follow-up retrospective study on 91 consecutive newly diagnosed acute promyelocytic leukaemia (APL) patients. Induction and consolidation therapy were well-tolerated by most patients. Of the 79 patients who were initially treated with the all-trans retinoic acid (ATRA)-containing regimens, there were 3 haemorrhagic deaths during the first period of therapy (4%) and one in consolidation which was due to infection. Following consolidation, molecular assessment of response was performed on 67 patients, and 66 were found to have achieved cytogenetic and molecular remission (98%). After a median follow-up of 100 months (12-192), 10 of the 75 patients who achieved complete remission (13%) relapsed. Seventy-eight percent of the patients were expected to be alive at 14 years from diagnosis, i.e., 90 and 48% of patients of intermediate-low risk and high risk at presentation, respectively (p=0.0009). Sixty-nine patients were in molecular remission after firstline and/or salvage therapy (74%). To date, 4 patients out of the 91 have undergone salvage allogeneic transplant (4%).

Original languageEnglish
Pages (from-to)1045-1052
Number of pages8
JournalOncology Reports
Volume21
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • Acute promyelocytic leukaemia
  • All-trans retinoic acid
  • Fluorescent in situ hybridization
  • PML-RARα

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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