Several nuclear events during apoptosis depend on caspase-3 activation but do not constitute a common pathway

Lisa Trisciuoglio, Marco Emilio Bianchi

Research output: Contribution to journalArticle

Abstract

A number of nuclear events occur during apoptosis, including DNA laddering, nuclear lamina breakdown, phosphorylation of histones H2B and histone H2AX, and the tight binding to chromatin of HMGB1 and CAD, the nuclease responsible for DNA laddering. We have performed an epistasis analysis to investigate whether these events cluster together in pathways. We find that all depend directly or indirectly on caspase-3 activation. CAD activation, H2AX phosphorylation and DNA laddering cluster together into a pathway, but all other events appear to be independent of each other downstream of caspase-3, and likely evolved subject to different functional pressures.

Original languageEnglish
Article numbere6234
JournalPLoS One
Volume4
Issue number7
DOIs
Publication statusPublished - Jul 29 2009

ASJC Scopus subject areas

  • Agricultural and Biological Sciences(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

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