Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions

G. Di Gennaro, L. G. Grammaldo, P. P. Quarato, V. Esposito, A. Mascia, A. Sparano, G. N. Meldolesi, A. Picardi

Research output: Contribution to journalArticle

Abstract

A comprehensive neuropsychological assessment was performed on a 38-year-old woman with drug-resistant right temporal lobe epilepsy before temporal lobectomy, during a 2-year follow-up period, and approximately 3 years after surgery when she developed a malignant glioma in the left medial temporal lobe (MTL). Both before and after epilepsy surgery, memory function was normal. When the tumour was discovered, the patient suffered from severe retrograde and anterograde amnesia, whereas working memory and the other cognitive abilities were preserved. Compared with other cases of bilateral temporal lesion, this case is peculiar because the damage occurred on two distinct occasions. It suggests that only one MTL can allow normal memory function, or can take over the function normally subserved by a dysfunctional contralateral MTL when the dysfunction is marked and prolonged, such as in chronic epilepsy.

Original languageEnglish
Pages (from-to)129-133
Number of pages5
JournalNeurological Sciences
Volume27
Issue number2
DOIs
Publication statusPublished - Jun 2006

Fingerprint

Amnesia
Temporal Lobe
Epilepsy
Anterograde Amnesia
Retrograde Amnesia
Aptitude
Temporal Lobe Epilepsy
Short-Term Memory
Glioma
Pharmaceutical Preparations
Neoplasms

Keywords

  • Brain tumour
  • Epilepsy surgery
  • Global amnesia
  • Memory
  • Neuropsychological tests
  • Temporal lobe epilepsy

ASJC Scopus subject areas

  • Neuroscience(all)
  • Clinical Neurology

Cite this

Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions. / Di Gennaro, G.; Grammaldo, L. G.; Quarato, P. P.; Esposito, V.; Mascia, A.; Sparano, A.; Meldolesi, G. N.; Picardi, A.

In: Neurological Sciences, Vol. 27, No. 2, 06.2006, p. 129-133.

Research output: Contribution to journalArticle

@article{82f69dd8af6c4a4093af850a894096b7,
title = "Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions",
abstract = "A comprehensive neuropsychological assessment was performed on a 38-year-old woman with drug-resistant right temporal lobe epilepsy before temporal lobectomy, during a 2-year follow-up period, and approximately 3 years after surgery when she developed a malignant glioma in the left medial temporal lobe (MTL). Both before and after epilepsy surgery, memory function was normal. When the tumour was discovered, the patient suffered from severe retrograde and anterograde amnesia, whereas working memory and the other cognitive abilities were preserved. Compared with other cases of bilateral temporal lesion, this case is peculiar because the damage occurred on two distinct occasions. It suggests that only one MTL can allow normal memory function, or can take over the function normally subserved by a dysfunctional contralateral MTL when the dysfunction is marked and prolonged, such as in chronic epilepsy.",
keywords = "Brain tumour, Epilepsy surgery, Global amnesia, Memory, Neuropsychological tests, Temporal lobe epilepsy",
author = "{Di Gennaro}, G. and Grammaldo, {L. G.} and Quarato, {P. P.} and V. Esposito and A. Mascia and A. Sparano and Meldolesi, {G. N.} and A. Picardi",
year = "2006",
month = "6",
doi = "10.1007/s10072-006-0614-y",
language = "English",
volume = "27",
pages = "129--133",
journal = "Neurological Sciences",
issn = "1590-1874",
publisher = "Springer-Verlag Italia s.r.l.",
number = "2",

}

TY - JOUR

T1 - Severe amnesia following bilateral medial temporal lobe damage occurring on two distinct occasions

AU - Di Gennaro, G.

AU - Grammaldo, L. G.

AU - Quarato, P. P.

AU - Esposito, V.

AU - Mascia, A.

AU - Sparano, A.

AU - Meldolesi, G. N.

AU - Picardi, A.

PY - 2006/6

Y1 - 2006/6

N2 - A comprehensive neuropsychological assessment was performed on a 38-year-old woman with drug-resistant right temporal lobe epilepsy before temporal lobectomy, during a 2-year follow-up period, and approximately 3 years after surgery when she developed a malignant glioma in the left medial temporal lobe (MTL). Both before and after epilepsy surgery, memory function was normal. When the tumour was discovered, the patient suffered from severe retrograde and anterograde amnesia, whereas working memory and the other cognitive abilities were preserved. Compared with other cases of bilateral temporal lesion, this case is peculiar because the damage occurred on two distinct occasions. It suggests that only one MTL can allow normal memory function, or can take over the function normally subserved by a dysfunctional contralateral MTL when the dysfunction is marked and prolonged, such as in chronic epilepsy.

AB - A comprehensive neuropsychological assessment was performed on a 38-year-old woman with drug-resistant right temporal lobe epilepsy before temporal lobectomy, during a 2-year follow-up period, and approximately 3 years after surgery when she developed a malignant glioma in the left medial temporal lobe (MTL). Both before and after epilepsy surgery, memory function was normal. When the tumour was discovered, the patient suffered from severe retrograde and anterograde amnesia, whereas working memory and the other cognitive abilities were preserved. Compared with other cases of bilateral temporal lesion, this case is peculiar because the damage occurred on two distinct occasions. It suggests that only one MTL can allow normal memory function, or can take over the function normally subserved by a dysfunctional contralateral MTL when the dysfunction is marked and prolonged, such as in chronic epilepsy.

KW - Brain tumour

KW - Epilepsy surgery

KW - Global amnesia

KW - Memory

KW - Neuropsychological tests

KW - Temporal lobe epilepsy

UR - http://www.scopus.com/inward/record.url?scp=33745603490&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33745603490&partnerID=8YFLogxK

U2 - 10.1007/s10072-006-0614-y

DO - 10.1007/s10072-006-0614-y

M3 - Article

C2 - 16816912

AN - SCOPUS:33745603490

VL - 27

SP - 129

EP - 133

JO - Neurological Sciences

JF - Neurological Sciences

SN - 1590-1874

IS - 2

ER -