Severe Asthma and Allergy: A Pediatric Perspective

Research output: Contribution to journalReview article

Abstract

Severe asthma in children is associated with significant morbidity and lung function decline. It represents a highly heterogeneous disorder with multiple clinical phenotypes. As its management is demanding, the social and economic burden are impressive. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Allergen sensitization and/or allergy symptoms may predict asthma onset and severity. A better framing of "allergen sensitization" and understanding of mechanisms underlying progression of atopic march could improve the management and the long-term outcomes of pediatric severe asthma. This review focuses on the current knowledge about interactions between severe asthma and allergies.

Original languageEnglish
Pages (from-to)28
JournalFrontiers in Pediatrics
Volume7
DOIs
Publication statusPublished - Feb 11 2019

Fingerprint

Hypersensitivity
Asthma
Pediatrics
Allergens
Morbidity
Economics
Phenotype
Lung
Therapeutics

Cite this

@article{8aa8734344444eddb73a2d96b0d87da1,
title = "Severe Asthma and Allergy: A Pediatric Perspective",
abstract = "Severe asthma in children is associated with significant morbidity and lung function decline. It represents a highly heterogeneous disorder with multiple clinical phenotypes. As its management is demanding, the social and economic burden are impressive. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Allergen sensitization and/or allergy symptoms may predict asthma onset and severity. A better framing of {"}allergen sensitization{"} and understanding of mechanisms underlying progression of atopic march could improve the management and the long-term outcomes of pediatric severe asthma. This review focuses on the current knowledge about interactions between severe asthma and allergies.",
author = "Stefania Arasi and Federica Porcaro and Renato Cutrera and Fiocchi, {Alessandro G}",
year = "2019",
month = "2",
day = "11",
doi = "10.3389/fped.2019.00028",
language = "English",
volume = "7",
pages = "28",
journal = "Frontiers in Pediatrics",
issn = "2296-2360",
publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - Severe Asthma and Allergy

T2 - A Pediatric Perspective

AU - Arasi, Stefania

AU - Porcaro, Federica

AU - Cutrera, Renato

AU - Fiocchi, Alessandro G

PY - 2019/2/11

Y1 - 2019/2/11

N2 - Severe asthma in children is associated with significant morbidity and lung function decline. It represents a highly heterogeneous disorder with multiple clinical phenotypes. As its management is demanding, the social and economic burden are impressive. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Allergen sensitization and/or allergy symptoms may predict asthma onset and severity. A better framing of "allergen sensitization" and understanding of mechanisms underlying progression of atopic march could improve the management and the long-term outcomes of pediatric severe asthma. This review focuses on the current knowledge about interactions between severe asthma and allergies.

AB - Severe asthma in children is associated with significant morbidity and lung function decline. It represents a highly heterogeneous disorder with multiple clinical phenotypes. As its management is demanding, the social and economic burden are impressive. Several co-morbidities may contribute to worsen asthma control and complicate diagnostic and therapeutic management of severe asthmatic patients. Allergen sensitization and/or allergy symptoms may predict asthma onset and severity. A better framing of "allergen sensitization" and understanding of mechanisms underlying progression of atopic march could improve the management and the long-term outcomes of pediatric severe asthma. This review focuses on the current knowledge about interactions between severe asthma and allergies.

U2 - 10.3389/fped.2019.00028

DO - 10.3389/fped.2019.00028

M3 - Review article

C2 - 30805326

VL - 7

SP - 28

JO - Frontiers in Pediatrics

JF - Frontiers in Pediatrics

SN - 2296-2360

ER -