Severe asthma in children: Current goals and unmet needs

Amelia Licari, Sara Manti, Elena Chiappini, Giorgio Ciprandi, Gian Luigi Marseglia

Research output: Contribution to journalArticlepeer-review

Abstract

Severe asthma in children is considered a complex and heterogeneous disease. A multidisciplinary assessment is required to correctly identify and manage these children because they potentially need close monitoring and additional treatment with advanced targeted therapies. Recent research efforts focused on the identification of epidemiologic, clinical, and functional characteristics of the disease in the pediatric age. Novel findings on the molecular mechanisms underlying severe asthma have led to the recognition of different endotypes and related biomarkers able to predict the response to advanced biologic therapies. Progress in our knowledge of severe asthma has occurred with the introduction of biologic therapies. Future goals in asthma care include the identification of the links between phenotypes and endotypes, as well as the identification of novel predictive biomarkers. They will help to select candidates for innovative biologic therapies and ultimately improve outcomes in children with severe asthma.

Original languageEnglish
Pages (from-to)40-42
Number of pages3
JournalPediatric Allergy and Immunology
Volume31
Issue numberS24
DOIs
Publication statusPublished - Feb 1 2020

Keywords

  • anti-IgE
  • children
  • corticosteroids
  • omalizumab
  • severe asthma

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Immunology and Allergy
  • Immunology

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