Abstract
Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
| Original language | English |
|---|---|
| Pages (from-to) | 216-231 |
| Number of pages | 16 |
| Journal | International Archives of Allergy and Immunology |
| Volume | 158 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Jun 2012 |
Keywords
- Asthma
- Atopic dermatitis
- Immunoglobulin E
- Rhinitis
- Rhinosinusitis
- Urticaria
ASJC Scopus subject areas
- Immunology and Allergy
- Immunology
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Severe chronic allergic (and related) diseases : A uniform approach - A MeDALL - GA2 LEN - ARIA position paper. / Bousquet, J.; Anto, J. M.; Demoly, P.; Schünemann, H. J.; Togias, A.; Akdis, M.; Auffray, C.; Bachert, C.; Bieber, T.; Bousquet, P. J.; Carlsen, K. H.; Casale, T. B.; Cruz, A. A.; Keil, T.; Lodrup Carlsen, K. C.; Maurer, M.; Ohta, K.; Papadopoulos, N. G.; Roman Rodriguez, M.; Samolinski, B.; Agache, I.; Andrianarisoa, A.; Ang, C. S.; Annesi-Maesano, I.; Ballester, F.; Baena-Cagnani, C. E.; Basagaña, X.; Bateman, E. D.; Bel, E. H.; Bedbrook, A.; Beghé, B.; Beji, M.; Ben Kheder, A.; Benet, M.; Bennoor, K. S.; Bergmann, K. C.; Berrissoul, F.; Bindslev Jensen, C.; Bleecker, E. R.; Bonini, S.; Boner, A. L.; Boulet, L. P.; Brightling, C. E.; Brozek, J. L.; Bush, A.; Busse, W. W.; Camargos, P. A M; Canonica, G. W.; Carr, W.; Cesario, A.; Chen, Y. Z.; Chiriac, A. M.; Costa, D. J.; Cox, L.; Custovic, A.; Dahl, R.; Darsow, U.; Didi, T.; Dolen, W. K.; Douagui, H.; Dubakiene, R.; El-Meziane, A.; Fonseca, J. A.; Fokkens, W. J.; Fthenou, E.; Gamkrelidze, A.; Garcia-Aymerich, J.; Van Wijk, R. Gerth; Gimeno-Santos, E.; Guerra, S.; Haahtela, T.; Haddad, H.; Hellings, P. W.; Hellquist-Dahl, B.; Hohmann, C.; Howarth, P.; Hourihane, J. O.; Humbert, M.; Jacquemin, B.; Just, J.; Kalayci, O.; Kaliner, M. A.; Kauffmann, F.; Kerkhof, M.; Khayat, G.; Koffi N'Goran, B.; Kogevinas, M.; Koppelman, G. H.; Kowalski, M. L.; Kull, I.; Kuna, P.; Larenas, D.; Lavi, I.; Le, L. T.; Lieberman, P.; Lipworth, B.; Mahboub, B.; Makela, M. J.; Martin, F.; Martinez, F. D.; Marshall, G. D.; Mazon, A.; Melen, E.; Meltzer, E. O.; Mihaltan, F.; Mohammad, Y.; Mohammadi, A.; Momas, I.; Morais-Almeida, M.; Mullol, J.; Muraro, A.; Naclerio, R.; Nafti, S.; Namazova-Baranova, L.; Nawijn, M. C.; Nyembue, T. D.; Oddie, S.; O'Hehir, R. E.; Okamoto, Y.; Orru, M. P.; Ozdemir, C.; Ouedraogo, G. S.; Palkonen, S.; Panzner, P.; Passalacqua, G.; Pawankar, R.; Pigearias, B.; Pin, I.; Pinart, M.; Pison, C.; Popov, T. A.; Porta, D.; Postma, D. S.; Price, D.; Rabe, K. F.; Ratomaharo, J.; Reitamo, S.; Rezagui, D.; Ring, J.; Roberts, R.; Roca, J.; Rogala, B.; Romano, A.; Rosado-Pinto, J.; Ryan, D.; Sanchez-Borges, M.; Scadding, G. K.; Sheikh, A.; Simons, F. E R; Siroux, V.; Schmid-Grendelmeier, P. D.; Smit, H. A.; Sooronbaev, T.; Stein, R. T.; Sterk, P. J.; Sunyer, J.; Terreehorst, I.; Toskala, E.; Tremblay, Y.; Valenta, R.; Valeyre, D.; Vandenplas, O.; Van Weel, C.; Vassilaki, M.; Varraso, R.; Viegi, G.; Wang, D. Y.; Wickman, M.; Williams, D.; Wöhrl, S.; Wright, J.; Yorgancioglu, A.; Yusuf, O. M.; Zar, H. J.; Zernotti, M. E.; Zidarn, M.; Zhong, N.; Zuberbier, T.
In: International Archives of Allergy and Immunology, Vol. 158, No. 3, 06.2012, p. 216-231.Research output: Contribution to journal › Article › peer-review
}
TY - JOUR
T1 - Severe chronic allergic (and related) diseases
T2 - A uniform approach - A MeDALL - GA2 LEN - ARIA position paper
AU - Bousquet, J.
AU - Anto, J. M.
AU - Demoly, P.
AU - Schünemann, H. J.
AU - Togias, A.
AU - Akdis, M.
AU - Auffray, C.
AU - Bachert, C.
AU - Bieber, T.
AU - Bousquet, P. J.
AU - Carlsen, K. H.
AU - Casale, T. B.
AU - Cruz, A. A.
AU - Keil, T.
AU - Lodrup Carlsen, K. C.
AU - Maurer, M.
AU - Ohta, K.
AU - Papadopoulos, N. G.
AU - Roman Rodriguez, M.
AU - Samolinski, B.
AU - Agache, I.
AU - Andrianarisoa, A.
AU - Ang, C. S.
AU - Annesi-Maesano, I.
AU - Ballester, F.
AU - Baena-Cagnani, C. E.
AU - Basagaña, X.
AU - Bateman, E. D.
AU - Bel, E. H.
AU - Bedbrook, A.
AU - Beghé, B.
AU - Beji, M.
AU - Ben Kheder, A.
AU - Benet, M.
AU - Bennoor, K. S.
AU - Bergmann, K. C.
AU - Berrissoul, F.
AU - Bindslev Jensen, C.
AU - Bleecker, E. R.
AU - Bonini, S.
AU - Boner, A. L.
AU - Boulet, L. P.
AU - Brightling, C. E.
AU - Brozek, J. L.
AU - Bush, A.
AU - Busse, W. W.
AU - Camargos, P. A M
AU - Canonica, G. W.
AU - Carr, W.
AU - Cesario, A.
AU - Chen, Y. Z.
AU - Chiriac, A. M.
AU - Costa, D. J.
AU - Cox, L.
AU - Custovic, A.
AU - Dahl, R.
AU - Darsow, U.
AU - Didi, T.
AU - Dolen, W. K.
AU - Douagui, H.
AU - Dubakiene, R.
AU - El-Meziane, A.
AU - Fonseca, J. A.
AU - Fokkens, W. J.
AU - Fthenou, E.
AU - Gamkrelidze, A.
AU - Garcia-Aymerich, J.
AU - Van Wijk, R. Gerth
AU - Gimeno-Santos, E.
AU - Guerra, S.
AU - Haahtela, T.
AU - Haddad, H.
AU - Hellings, P. W.
AU - Hellquist-Dahl, B.
AU - Hohmann, C.
AU - Howarth, P.
AU - Hourihane, J. O.
AU - Humbert, M.
AU - Jacquemin, B.
AU - Just, J.
AU - Kalayci, O.
AU - Kaliner, M. A.
AU - Kauffmann, F.
AU - Kerkhof, M.
AU - Khayat, G.
AU - Koffi N'Goran, B.
AU - Kogevinas, M.
AU - Koppelman, G. H.
AU - Kowalski, M. L.
AU - Kull, I.
AU - Kuna, P.
AU - Larenas, D.
AU - Lavi, I.
AU - Le, L. T.
AU - Lieberman, P.
AU - Lipworth, B.
AU - Mahboub, B.
AU - Makela, M. J.
AU - Martin, F.
AU - Martinez, F. D.
AU - Marshall, G. D.
AU - Mazon, A.
AU - Melen, E.
AU - Meltzer, E. O.
AU - Mihaltan, F.
AU - Mohammad, Y.
AU - Mohammadi, A.
AU - Momas, I.
AU - Morais-Almeida, M.
AU - Mullol, J.
AU - Muraro, A.
AU - Naclerio, R.
AU - Nafti, S.
AU - Namazova-Baranova, L.
AU - Nawijn, M. C.
AU - Nyembue, T. D.
AU - Oddie, S.
AU - O'Hehir, R. E.
AU - Okamoto, Y.
AU - Orru, M. P.
AU - Ozdemir, C.
AU - Ouedraogo, G. S.
AU - Palkonen, S.
AU - Panzner, P.
AU - Passalacqua, G.
AU - Pawankar, R.
AU - Pigearias, B.
AU - Pin, I.
AU - Pinart, M.
AU - Pison, C.
AU - Popov, T. A.
AU - Porta, D.
AU - Postma, D. S.
AU - Price, D.
AU - Rabe, K. F.
AU - Ratomaharo, J.
AU - Reitamo, S.
AU - Rezagui, D.
AU - Ring, J.
AU - Roberts, R.
AU - Roca, J.
AU - Rogala, B.
AU - Romano, A.
AU - Rosado-Pinto, J.
AU - Ryan, D.
AU - Sanchez-Borges, M.
AU - Scadding, G. K.
AU - Sheikh, A.
AU - Simons, F. E R
AU - Siroux, V.
AU - Schmid-Grendelmeier, P. D.
AU - Smit, H. A.
AU - Sooronbaev, T.
AU - Stein, R. T.
AU - Sterk, P. J.
AU - Sunyer, J.
AU - Terreehorst, I.
AU - Toskala, E.
AU - Tremblay, Y.
AU - Valenta, R.
AU - Valeyre, D.
AU - Vandenplas, O.
AU - Van Weel, C.
AU - Vassilaki, M.
AU - Varraso, R.
AU - Viegi, G.
AU - Wang, D. Y.
AU - Wickman, M.
AU - Williams, D.
AU - Wöhrl, S.
AU - Wright, J.
AU - Yorgancioglu, A.
AU - Yusuf, O. M.
AU - Zar, H. J.
AU - Zernotti, M. E.
AU - Zidarn, M.
AU - Zhong, N.
AU - Zuberbier, T.
PY - 2012/6
Y1 - 2012/6
N2 - Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
AB - Concepts of disease severity, activity, control and responsiveness to treatment are linked but different. Severity refers to the loss of function of the organs induced by the disease process or to the occurrence of severe acute exacerbations. Severity may vary over time and needs regular follow-up. Control is the degree to which therapy goals are currently met. These concepts have evolved over time for asthma in guidelines, task forces or consensus meetings. The aim of this paper is to generalize the approach of the uniform definition of severe asthma presented to WHO for chronic allergic and associated diseases (rhinitis, chronic rhinosinusitis, chronic urticaria and atopic dermatitis) in order to have a uniform definition of severity, control and risk, usable in most situations. It is based on the appropriate diagnosis, availability and accessibility of treatments, treatment responsiveness and associated factors such as comorbidities and risk factors. This uniform definition will allow a better definition of the phenotypes of severe allergic (and related) diseases for clinical practice, research (including epidemiology), public health purposes, education and the discovery of novel therapies.
KW - Asthma
KW - Atopic dermatitis
KW - Immunoglobulin E
KW - Rhinitis
KW - Rhinosinusitis
KW - Urticaria
UR - http://www.scopus.com/inward/record.url?scp=84862136708&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84862136708&partnerID=8YFLogxK
U2 - 10.1159/000332924
DO - 10.1159/000332924
M3 - Article
C2 - 22382913
AN - SCOPUS:84862136708
VL - 158
SP - 216
EP - 231
JO - International Archives of Allergy and Immunology
JF - International Archives of Allergy and Immunology
SN - 1018-2438
IS - 3
ER -