Abstract
Objectives: 1) To define the best outcome of severe Congenital Diaphragmatic Hernia (CDH); 2) to critically evaluate deaths in order to identify possible criteria of exclusion from ECMO; and 3) to identify CDHs which could benefit from ECMO. Materials and Methods: 63 severe CDHs, 35 (55.6%) survivors and 28 (44.4%) nonsurvivors, subdivided into 2 groups according to age at death: Group I dying at 12 ≤ 24 hours, and Group II dying at > 24 hours after birth. The three groups were compared on the basis of prenatal diagnosis, polyhydramnios, gestational age, birth weight, pneumothorax, best values of postductal PaCO2 and PaO2, clinical and echocardiographic signs of persistent pulmonary hypertension, and severity of pulmonary hypoplasia (i.e., body weight to bilateral lung weight ratio at autopsy). Results: PaCO2, PaO2 and degree of pulmonary hypoplasia were significantly worse in Group I compared to Group II and to survivors. PaCO2 and PaO2 in Group II did not differ significantly from those of survivors. Conclusions: In severe CDH it is possible: 1) to achieve a survival rate of 56% without ECMO; 2) to identify a group of patients (Group 1 = 27%) with severe pulmonary hypoplasia who would probably die even with ECMO; and 3) to identify a group of patients (Group II = 17%) who might benefit from ECMO treatment.
| Original language | English |
|---|---|
| Pages (from-to) | 95-100 |
| Number of pages | 6 |
| Journal | European Journal of Pediatric Surgery |
| Volume | 12 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2002 |
Fingerprint
Keywords
- Congenital diaphragmatic hernia
- ECMO
- Pulmonary hypoplasia prediction
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
Cite this
Severe Congenital Diaphragmatic Hernia (CDH) : A critical analysis of eight years' experience. / Bagolan, Pietro; Casaccia, G.; Nahom, A.; Trucchi, A.; Zangari, A.; Laviani, R.; Pirozzi, N.; Di Liso, G.; Orzalesi, M.
In: European Journal of Pediatric Surgery, Vol. 12, No. 2, 2002, p. 95-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Severe Congenital Diaphragmatic Hernia (CDH)
T2 - A critical analysis of eight years' experience
AU - Bagolan, Pietro
AU - Casaccia, G.
AU - Nahom, A.
AU - Trucchi, A.
AU - Zangari, A.
AU - Laviani, R.
AU - Pirozzi, N.
AU - Di Liso, G.
AU - Orzalesi, M.
PY - 2002
Y1 - 2002
N2 - Objectives: 1) To define the best outcome of severe Congenital Diaphragmatic Hernia (CDH); 2) to critically evaluate deaths in order to identify possible criteria of exclusion from ECMO; and 3) to identify CDHs which could benefit from ECMO. Materials and Methods: 63 severe CDHs, 35 (55.6%) survivors and 28 (44.4%) nonsurvivors, subdivided into 2 groups according to age at death: Group I dying at 12 ≤ 24 hours, and Group II dying at > 24 hours after birth. The three groups were compared on the basis of prenatal diagnosis, polyhydramnios, gestational age, birth weight, pneumothorax, best values of postductal PaCO2 and PaO2, clinical and echocardiographic signs of persistent pulmonary hypertension, and severity of pulmonary hypoplasia (i.e., body weight to bilateral lung weight ratio at autopsy). Results: PaCO2, PaO2 and degree of pulmonary hypoplasia were significantly worse in Group I compared to Group II and to survivors. PaCO2 and PaO2 in Group II did not differ significantly from those of survivors. Conclusions: In severe CDH it is possible: 1) to achieve a survival rate of 56% without ECMO; 2) to identify a group of patients (Group 1 = 27%) with severe pulmonary hypoplasia who would probably die even with ECMO; and 3) to identify a group of patients (Group II = 17%) who might benefit from ECMO treatment.
AB - Objectives: 1) To define the best outcome of severe Congenital Diaphragmatic Hernia (CDH); 2) to critically evaluate deaths in order to identify possible criteria of exclusion from ECMO; and 3) to identify CDHs which could benefit from ECMO. Materials and Methods: 63 severe CDHs, 35 (55.6%) survivors and 28 (44.4%) nonsurvivors, subdivided into 2 groups according to age at death: Group I dying at 12 ≤ 24 hours, and Group II dying at > 24 hours after birth. The three groups were compared on the basis of prenatal diagnosis, polyhydramnios, gestational age, birth weight, pneumothorax, best values of postductal PaCO2 and PaO2, clinical and echocardiographic signs of persistent pulmonary hypertension, and severity of pulmonary hypoplasia (i.e., body weight to bilateral lung weight ratio at autopsy). Results: PaCO2, PaO2 and degree of pulmonary hypoplasia were significantly worse in Group I compared to Group II and to survivors. PaCO2 and PaO2 in Group II did not differ significantly from those of survivors. Conclusions: In severe CDH it is possible: 1) to achieve a survival rate of 56% without ECMO; 2) to identify a group of patients (Group 1 = 27%) with severe pulmonary hypoplasia who would probably die even with ECMO; and 3) to identify a group of patients (Group II = 17%) who might benefit from ECMO treatment.
KW - Congenital diaphragmatic hernia
KW - ECMO
KW - Pulmonary hypoplasia prediction
UR - http://www.scopus.com/inward/record.url?scp=0036104747&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0036104747&partnerID=8YFLogxK
U2 - 10.1055/s-2002-30159
DO - 10.1055/s-2002-30159
M3 - Article
VL - 12
SP - 95
EP - 100
JO - European Journal of Pediatric Surgery
JF - European Journal of Pediatric Surgery
SN - 0939-7248
IS - 2
ER -