Severe cushing’s syndrome related to a small pulmonary carcinoid with widespread dissemination

Research output: Contribution to journalArticle

Abstract

Cushing’s syndrome (CS) is characterized by the overproduction of cortisol that may result in significant morbidity and mortality if left untreated. CS is very rarely caused by ectopic adrenocorticotropic hormone production from several tumors, although pulmonary neuroendocrine tumors (pNETs) are the most common etiology. It is controversial whether such tumors are more clinically aggressive than other pNETs. We herein report an unusual case of severe ectopic CS caused by a small pulmonary carcinoid in the lung with massive neoplastic dissemination to the liver. We highlight and discuss the unusual clinical onset, with diagnostic and therapeutic criticism, of this rare entity.

Original languageEnglish
Pages (from-to)477-480
Number of pages4
JournalInternal Medicine
Volume54
Issue number5
DOIs
Publication statusPublished - Mar 1 2015

Fingerprint

Cushing Syndrome
Carcinoid Tumor
Lung
Neuroendocrine Tumors
Ectopic Hormones
Adrenocorticotropic Hormone
Hydrocortisone
Neoplasms
Morbidity
Mortality
Liver
Therapeutics

Keywords

  • Bronchial carcinoids
  • Cushing’s syndrome
  • PET/CT scan

ASJC Scopus subject areas

  • Internal Medicine
  • Medicine(all)

Cite this

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title = "Severe cushing’s syndrome related to a small pulmonary carcinoid with widespread dissemination",
abstract = "Cushing’s syndrome (CS) is characterized by the overproduction of cortisol that may result in significant morbidity and mortality if left untreated. CS is very rarely caused by ectopic adrenocorticotropic hormone production from several tumors, although pulmonary neuroendocrine tumors (pNETs) are the most common etiology. It is controversial whether such tumors are more clinically aggressive than other pNETs. We herein report an unusual case of severe ectopic CS caused by a small pulmonary carcinoid in the lung with massive neoplastic dissemination to the liver. We highlight and discuss the unusual clinical onset, with diagnostic and therapeutic criticism, of this rare entity.",
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AU - Lococo, Filippo

AU - Negro, Aurelio

AU - Zanelli, Francesca

AU - Valli, Riccardo

AU - Filice, Angelina

AU - Rapicetta, Cristian

AU - Paci, Massimiliano

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AB - Cushing’s syndrome (CS) is characterized by the overproduction of cortisol that may result in significant morbidity and mortality if left untreated. CS is very rarely caused by ectopic adrenocorticotropic hormone production from several tumors, although pulmonary neuroendocrine tumors (pNETs) are the most common etiology. It is controversial whether such tumors are more clinically aggressive than other pNETs. We herein report an unusual case of severe ectopic CS caused by a small pulmonary carcinoid in the lung with massive neoplastic dissemination to the liver. We highlight and discuss the unusual clinical onset, with diagnostic and therapeutic criticism, of this rare entity.

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