Anemia hemolítica grave causada por hemoglobina Hammersmith

Translated title of the contribution: Severe hemolytic anemia due to hemoglobin Hammersmith

Silvia J Eandi Eberle, Nélida Noguera, Karina Calvo, María Ojeda, Irma Bragós, Arianna Pratti, Ángela Milani, Héctor Targovnik, Gabriela Sciuccati, Lilian Díaz, Mariana Bonduel, Aurora Feliú Torres

Research output: Contribution to journalArticlepeer-review


Most of the hemoglobin variants are the result of single amino acid replacement in one of the globin chains. In many cases, these hemoglobinopathies are harmless, while in others they determine alterations in the physical and chemical properties, raising clinical manifestations of variable severity. In the unstable hemoglobinopathies, the changes reduce solubility, inducing the formation of precipitates of denaturated hemoglobin (Heinz bodies), which damage the membrane and finally destroy the red blood cells prematurely. Up to now, more than 150 different unstable hemoglobins have been described; most of them cause chronic hemolysis, increased by infections or drugs. We report the clinical presentation of an unstable hemoglobin (hemoglobin Hammersmith) in a girl with severe hemolytic anemia, splenomegaly and red blood cell requirement.

Translated title of the contributionSevere hemolytic anemia due to hemoglobin Hammersmith
Original languageSpanish
Pages (from-to)347-349
Number of pages3
JournalArchivos Argentinos de Pediatria
Issue number4
Publication statusPublished - 2009


  • Abnormal hemoglobin
  • Hemolytic anemia
  • Unstable hemoglobin

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health


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