Severe hyperbilirubinemia in an HIV-HCV coinfected patient starting the 3D regimen that resolved after TDM-guided atazanavir dose reduction

Dario Cattaneo, Agostino Riva, Emilio Clementi, Laura Milazzo, Cristina Gervasoni

Research output: Contribution to journalArticle

Abstract

ABSTRACT: The combination of ombitasvir, dasabuvir and paritaprevir/ritonavir (referred as the 3D regimen) has proven to be associated with high sustained virologic response and optimal tolerability in hepatitis C virus-infected patients. Here we describe an HIV-HCV coinfected patient who experienced a grade 4 hyperbilirubinemia and a 2.5-fold increase in the ATV plasma trough concentrations few days after the start of 3D-based antiviral therapy who benefited from an ATV dose reduction guided by therapeutic drug monitoring.

Original languageEnglish
Pages (from-to)285-287
JournalTherapeutic Drug Monitoring
DOIs
Publication statusPublished - 2016

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology

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