Hypercalcémie sévère et lupus érythémateux disséminé

Translated title of the contribution: Severe hypercalcemia and systemic lupus erythematosus.

Carmine Gazzaruso, Carlo Maurizio Montecucco, Diego Geroldi, Adriana Garzaniti, Giorgio Finardi

Research output: Contribution to journalArticle

Abstract

A rare case of severe hypercalcemia strongly associated with systemic lupus erythematosus (SLE) is reported. On admission, a young woman showed severe hypercalcemia and photosensitivity. Criteria for diagnosis of SLE were not sufficient. All causes of hypercalcemia were excluded. Radiographs of the skeleton were normal. One year later diagnosis of SLE was evident. In addition, diffuse and severe osteopenia and chest deformities had occurred. The treatment of SLE normalized persistently calcemia. Mild elevation of calcium levels occurred during flares of SLE. It has been hypothesized that hypercalcemia in patients with SLE could be caused by the presence of stimulatory anti-PTH receptor antibodies. This case report suggests that in patients with severe hypercalcemia associated with SLE early diagnosis and treatment of SLE may prevent bone loss. In these patients the prevention of severe bone damage is very important. Indeed severe osteopenia may favour skeletal deformities and fractures; in addition it may represent a serious obstacle in using adequate doses of glucocorticoids for treatment of SLE.

Original languageFrench
Pages (from-to)646-650
Number of pages5
JournalRevue du Rhumatisme (Edition Francaise)
Volume67
Issue number8
Publication statusPublished - Oct 2000

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Keywords

  • Hypercalcémie
  • Hypercalcemia
  • Lupus érythémateux disséminé
  • Systemic lupus erythematosus

ASJC Scopus subject areas

  • Orthopedics and Sports Medicine

Cite this

Gazzaruso, C., Maurizio Montecucco, C., Geroldi, D., Garzaniti, A., & Finardi, G. (2000). Hypercalcémie sévère et lupus érythémateux disséminé. Revue du Rhumatisme (Edition Francaise), 67(8), 646-650.