Severe hyperlipemia in a young child with diabetic ketoacidosis

Carla Bizzarri, S. Calandra, M. Cappa

Research output: Contribution to journalArticle

Abstract

Hypertriglyceridemia is common in poorly controlled diabetes. Triglyceride levels above 2000 mg/dl may result from an underlying genetic hyperlipemia, especially in patients with type 2 diabetes. Severe hyperlipemia with milky plasma has been described also at the onset of type 1 diabetes, but in this case it is usually transient. We report the case of a young child with massive hyperlipemia during ketoacidosis. No mutation of candidate genes was found. A transient lipoprotein lipase defect induced by insulin deficiency, in addition to insulin resistance, contributed to determine hyperlipemia.

Original languageEnglish
Pages (from-to)358-361
Number of pages4
JournalItalian Journal of Pediatrics
Volume32
Issue number6
Publication statusPublished - Dec 2006

Fingerprint

Diabetic Ketoacidosis
Hyperlipidemias
Ketosis
Lipoprotein Lipase
Hypertriglyceridemia
Type 1 Diabetes Mellitus
Type 2 Diabetes Mellitus
Insulin Resistance
Triglycerides
Insulin
Mutation
Genes

Keywords

  • Child
  • Diabetes
  • Insulin
  • Ketoacidosis
  • Lipids

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Cite this

Severe hyperlipemia in a young child with diabetic ketoacidosis. / Bizzarri, Carla; Calandra, S.; Cappa, M.

In: Italian Journal of Pediatrics, Vol. 32, No. 6, 12.2006, p. 358-361.

Research output: Contribution to journalArticle

@article{6aa3ef84e8d947bd90fe36f3a7aa25d4,
title = "Severe hyperlipemia in a young child with diabetic ketoacidosis",
abstract = "Hypertriglyceridemia is common in poorly controlled diabetes. Triglyceride levels above 2000 mg/dl may result from an underlying genetic hyperlipemia, especially in patients with type 2 diabetes. Severe hyperlipemia with milky plasma has been described also at the onset of type 1 diabetes, but in this case it is usually transient. We report the case of a young child with massive hyperlipemia during ketoacidosis. No mutation of candidate genes was found. A transient lipoprotein lipase defect induced by insulin deficiency, in addition to insulin resistance, contributed to determine hyperlipemia.",
keywords = "Child, Diabetes, Insulin, Ketoacidosis, Lipids",
author = "Carla Bizzarri and S. Calandra and M. Cappa",
year = "2006",
month = "12",
language = "English",
volume = "32",
pages = "358--361",
journal = "Italian Journal of Pediatrics",
issn = "1720-8424",
publisher = "BioMed Central Ltd.",
number = "6",

}

TY - JOUR

T1 - Severe hyperlipemia in a young child with diabetic ketoacidosis

AU - Bizzarri, Carla

AU - Calandra, S.

AU - Cappa, M.

PY - 2006/12

Y1 - 2006/12

N2 - Hypertriglyceridemia is common in poorly controlled diabetes. Triglyceride levels above 2000 mg/dl may result from an underlying genetic hyperlipemia, especially in patients with type 2 diabetes. Severe hyperlipemia with milky plasma has been described also at the onset of type 1 diabetes, but in this case it is usually transient. We report the case of a young child with massive hyperlipemia during ketoacidosis. No mutation of candidate genes was found. A transient lipoprotein lipase defect induced by insulin deficiency, in addition to insulin resistance, contributed to determine hyperlipemia.

AB - Hypertriglyceridemia is common in poorly controlled diabetes. Triglyceride levels above 2000 mg/dl may result from an underlying genetic hyperlipemia, especially in patients with type 2 diabetes. Severe hyperlipemia with milky plasma has been described also at the onset of type 1 diabetes, but in this case it is usually transient. We report the case of a young child with massive hyperlipemia during ketoacidosis. No mutation of candidate genes was found. A transient lipoprotein lipase defect induced by insulin deficiency, in addition to insulin resistance, contributed to determine hyperlipemia.

KW - Child

KW - Diabetes

KW - Insulin

KW - Ketoacidosis

KW - Lipids

UR - http://www.scopus.com/inward/record.url?scp=34247338127&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247338127&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:34247338127

VL - 32

SP - 358

EP - 361

JO - Italian Journal of Pediatrics

JF - Italian Journal of Pediatrics

SN - 1720-8424

IS - 6

ER -