Severe inflammatory myopathy in a pulmonary carcinoma patient treated with Pembrolizumab: An alert for myologists

L. Peverelli; A. De Rosa; E. Domina; P. Ciscato; G. Sita; D. Velardo; G. P. Comi

doi:10.3233/JND-200504

Severe inflammatory myopathy in a pulmonary carcinoma patient treated with Pembrolizumab: An alert for myologists

L. Peverelli, A. De Rosa, E. Domina, P. Ciscato, G. Sita, D. Velardo, G. P. Comi

Fondazione IRCCS Ca' Granda- Ospedale Maggiore Policlinico

Research output: Contribution to journal › Article › peer-review

Abstract

Immune-related adverse events (irAE) during the administration of immune-checkpoint inhibitors (ICIs) become more evident due to the increased use of these therapies. To remind the importance of early recognition of this phenomenon, we report a paradigmatic case characterized by severe systemic inflammatory myopathy and severe cardiac involvement that abruptly precipitated in an untoward ending after one single dose of Pembrolizumab.

Original language	English
Pages (from-to)	511-514
Number of pages	4
Journal	Journal of Neuromuscular Diseases
Volume	7
Issue number	4
DOIs	https://doi.org/10.3233/JND-200504
Publication status	Published - 2020

Keywords

immune-checkpoint inhibitors
immune-correlated adverse events
inflammatory myopathy
Pembrolizumab
pulmonary carcinoma

ASJC Scopus subject areas

Neurology
Clinical Neurology

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10.3233/JND-200504

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abstract = "Immune-related adverse events (irAE) during the administration of immune-checkpoint inhibitors (ICIs) become more evident due to the increased use of these therapies. To remind the importance of early recognition of this phenomenon, we report a paradigmatic case characterized by severe systemic inflammatory myopathy and severe cardiac involvement that abruptly precipitated in an untoward ending after one single dose of Pembrolizumab.",

keywords = "immune-checkpoint inhibitors, immune-correlated adverse events, inflammatory myopathy, Pembrolizumab, pulmonary carcinoma",

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T2 - An alert for myologists

AU - Peverelli, L.

AU - De Rosa, A.

AU - Domina, E.

AU - Ciscato, P.

AU - Sita, G.

AU - Velardo, D.

AU - Comi, G. P.

PY - 2020

Y1 - 2020

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AB - Immune-related adverse events (irAE) during the administration of immune-checkpoint inhibitors (ICIs) become more evident due to the increased use of these therapies. To remind the importance of early recognition of this phenomenon, we report a paradigmatic case characterized by severe systemic inflammatory myopathy and severe cardiac involvement that abruptly precipitated in an untoward ending after one single dose of Pembrolizumab.

KW - immune-checkpoint inhibitors

KW - immune-correlated adverse events

KW - inflammatory myopathy

KW - Pembrolizumab

KW - pulmonary carcinoma

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Severe inflammatory myopathy in a pulmonary carcinoma patient treated with Pembrolizumab: An alert for myologists

Abstract

Keywords

ASJC Scopus subject areas

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