Severe platelet dysfunction in a patient with autoantibodies against membrane glycoproteins IIb-IIIa

C. L. Balduini, G. Grignani, F. Sinigaglia, A. Bisio, L. Pacchiarini, D. Rota Scalabrini, C. Mauri, E. Ascari

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

A young woman affected by Hodgkin's disease developed chronic autoimmune thrombocytopenic purpura. Splenectomy induced normalization of her platelet count, but hemorrhagic symptoms did not disappear. The patient's platelets did not aggregate in response to collagen and ADP and the IgG fraction of the patient's plasma induced the same defect in normal platelets. The women's IgG recognized glycoproteins IIb and IIIa of normal platelet membranes. Prednisone therapy induced the disappearance of bleeding symptoms and the normalization of platelet aggregation.

Original languageEnglish
Pages (from-to)98-104
Number of pages7
JournalHaemostasis
Volume17
Issue number1-2
Publication statusPublished - 1987

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Platelet Membrane Glycoprotein IIb
Platelet Glycoprotein GPIIb-IIIa Complex
Autoantibodies
Blood Platelets
Immunoglobulin G
Idiopathic Thrombocytopenic Purpura
Splenectomy
Prednisone
Hodgkin Disease
Platelet Count
Platelet Aggregation
Adenosine Diphosphate
Collagen
Hemorrhage
Membranes
Therapeutics

ASJC Scopus subject areas

  • Hematology

Cite this

Balduini, C. L., Grignani, G., Sinigaglia, F., Bisio, A., Pacchiarini, L., Rota Scalabrini, D., ... Ascari, E. (1987). Severe platelet dysfunction in a patient with autoantibodies against membrane glycoproteins IIb-IIIa. Haemostasis, 17(1-2), 98-104.

Severe platelet dysfunction in a patient with autoantibodies against membrane glycoproteins IIb-IIIa. / Balduini, C. L.; Grignani, G.; Sinigaglia, F.; Bisio, A.; Pacchiarini, L.; Rota Scalabrini, D.; Mauri, C.; Ascari, E.

In: Haemostasis, Vol. 17, No. 1-2, 1987, p. 98-104.

Research output: Contribution to journalArticle

Balduini, CL, Grignani, G, Sinigaglia, F, Bisio, A, Pacchiarini, L, Rota Scalabrini, D, Mauri, C & Ascari, E 1987, 'Severe platelet dysfunction in a patient with autoantibodies against membrane glycoproteins IIb-IIIa', Haemostasis, vol. 17, no. 1-2, pp. 98-104.
Balduini, C. L. ; Grignani, G. ; Sinigaglia, F. ; Bisio, A. ; Pacchiarini, L. ; Rota Scalabrini, D. ; Mauri, C. ; Ascari, E. / Severe platelet dysfunction in a patient with autoantibodies against membrane glycoproteins IIb-IIIa. In: Haemostasis. 1987 ; Vol. 17, No. 1-2. pp. 98-104.
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