TY - JOUR
T1 - Severe type 2 diabetes induces reversible modifications of endothelial progenitor cells which are ameliorate by glycemic control
AU - De Pascale, Maria Rosaria
AU - Bruzzese, Giuseppe
AU - Crimi, Ettore
AU - Grimaldi, Vincenzo
AU - Liguori, Antonio
AU - Brongo, Sergio
AU - Barbieri, Michelangela
AU - Picascia, Antonietta
AU - Schiano, Concetta
AU - Sommese, Linda
AU - Ferrara, Nicola
AU - Paolisso, Giuseppe
AU - Napoli, Claudio
PY - 2016
Y1 - 2016
N2 - Background: Circulating endothelial progenitors cells (EPCs) play a critical role in neovascularization and endothelial repair. There is a growing evidence that hyperglycemia related to Diabetes Mellitus (DM) decreases EPC number and function so promoting vascular complications. Aim of the Study: This study investigated whether an intensive glycemic control regimen in Type 2 DM can increase the number of EPCs and restores their function. Methods: Sixty-two patients with Type 2 DM were studied. Patients were tested at baseline and after 3 months of an intensive regimen of glycemic control. The Type 2 DM group was compared to control group of subjects without diabetes. Patients with Type 2 DM (mean age 58.2±5.4 years, 25.6% women, disease duration of 15.4±6.3 years) had a baseline HgA1c of 8.7±0.5% and lower EPC levels (CD34+/KDR+) in comparison to healthy controls (p
AB - Background: Circulating endothelial progenitors cells (EPCs) play a critical role in neovascularization and endothelial repair. There is a growing evidence that hyperglycemia related to Diabetes Mellitus (DM) decreases EPC number and function so promoting vascular complications. Aim of the Study: This study investigated whether an intensive glycemic control regimen in Type 2 DM can increase the number of EPCs and restores their function. Methods: Sixty-two patients with Type 2 DM were studied. Patients were tested at baseline and after 3 months of an intensive regimen of glycemic control. The Type 2 DM group was compared to control group of subjects without diabetes. Patients with Type 2 DM (mean age 58.2±5.4 years, 25.6% women, disease duration of 15.4±6.3 years) had a baseline HgA1c of 8.7±0.5% and lower EPC levels (CD34+/KDR+) in comparison to healthy controls (p
KW - Endothelial progenitor cells
KW - Regenerative medicine
KW - Type 2 diabetes
KW - Vascular disease
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U2 - 10.15283/ijsc.2016.9.1.137
DO - 10.15283/ijsc.2016.9.1.137
M3 - Article
AN - SCOPUS:84970005737
VL - 9
SP - 137
EP - 144
JO - International Journal of Stem Cells
JF - International Journal of Stem Cells
SN - 2005-3606
IS - 1
ER -