Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin

Enzo Hrovatin, Elda Viel, Chiara Lestuzzi, Lucia Tartuferi, Fabio Zardo, Marco Brieda, Ermanno Dametto, Rita Piazza, Francesco Antonini-Canterin, Elda Vaccher, Nereo Meneguzzo, Gian Luigi Nicolosi

Research output: Contribution to journalArticle

Abstract

The antimetabolite 5-fluorouracil is frequently used in the therapy of various malignancies. Cardiotoxicity has frequently been described during treatment, but there is no common agreement on the need to perform cardiovascular monitoring of patients during 5-fluorouracil administration. We report the case of a young patient with an head-neck cancer on whom a continuous electrocardiogram recording was performed, documenting serious ventricular dysrhythmias in the presence of myocardial ischemia during 5-fluorouracil and cis-platin infusion.

Original languageEnglish
Pages (from-to)637-640
Number of pages4
JournalJournal of Cardiovascular Medicine
Volume7
Issue number8
DOIs
Publication statusPublished - Aug 2006

Keywords

  • 5-fluorouracil
  • Cardiotoxicity
  • Chemotherapy
  • cis-platin
  • Malignant dysrhythmias

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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  • Cite this

    Hrovatin, E., Viel, E., Lestuzzi, C., Tartuferi, L., Zardo, F., Brieda, M., Dametto, E., Piazza, R., Antonini-Canterin, F., Vaccher, E., Meneguzzo, N., & Nicolosi, G. L. (2006). Severe ventricular dysrhythmias and silent ischemia during infusion of the antimetabolite 5-fluorouracil and cis-platin. Journal of Cardiovascular Medicine, 7(8), 637-640. https://doi.org/10.2459/01.JCM.0000237914.12915.dd