Severe vesicoureteral reflux and chronic renal failure: A condition peculiar to male gender? Data from the italkid project

Giuseppina Marra, Chiara Oppezzo, Gianluigi Ardissino, Valeria Daccò, Sara Testa, Luigi Avolio, Emanuela Taioli, Fabio Sereni

Research output: Contribution to journalArticle

Abstract

Primary vesicoureteral reflux (VUR), one of the principal causes of chronic renal failure (CRF), occurs as a result of two distinct and sex-related mechanisms: congenital renal hypoplasia, which is prevalent in males, and acquired renal scarring in females. We used data from the ItalKid Project, a prospective population-based CRF registry of patients undergoing conservative treatment, to evaluate the gender distribution and severity of primary VUR, the age at diagnosis, and the diagnostic and therapeutic methods adopted in children with CRF. The prevalence of males (77.5%), the severity of VUR (grade IV-V), and the early age at diagnosis (18% prenatally) seem to suggest that congenital renal damage is the major cause of pediatric CRF.

Original languageEnglish
Pages (from-to)677-681
Number of pages5
JournalJournal of Pediatrics
Volume144
Issue number5
DOIs
Publication statusPublished - May 2004

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

Fingerprint Dive into the research topics of 'Severe vesicoureteral reflux and chronic renal failure: A condition peculiar to male gender? Data from the italkid project'. Together they form a unique fingerprint.

  • Cite this