Severe worsening of adult-onset Alexander disease after minor head trauma: Report of two patients and review of the literature

Research output: Contribution to journalArticlepeer-review

Abstract

Alexander disease (ALXDRD) is a rare astrocytic leukodystrophy caused by GFAP mutations. The adult-onset (AO) variant is usually characterized by gradual onset of spastic ataxia and bulbar symptoms with slowly progressive course. We report two AO-ALXDRD cases with rapid worsening after minor head trauma. In one of them, the only post-traumatic neuroimaging change was revealed by diffusion tensor imaging study. Our observations support the link between head trauma and ALXDRD progression, and suggest that this progression may be ascribed to microstructural changes. Clinicians should inform ALXDRD patients to minimize the risk of head trauma.

Original languageEnglish
Pages (from-to)221-223
Number of pages3
JournalJournal of Clinical Neuroscience
Volume75
DOIs
Publication statusPublished - May 2020

Keywords

  • Alexander disease
  • Leukoencephalopathies
  • Nervous system trauma

ASJC Scopus subject areas

  • Surgery
  • Neurology
  • Clinical Neurology
  • Physiology (medical)

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