Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid

Marco Carbone; George F. Mells; Greta Pells; Muhammad F. Dawwas; Julia L. Newton; Michael A. Heneghan; James M. Neuberger; Darren B. Day; Samantha J. Ducker; Richard N. Sandford; Graeme J. Alexander; David E J Jones

doi:10.1053/j.gastro.2012.12.005

Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid

Marco Carbone, George F. Mells, Greta Pells, Muhammad F. Dawwas, Julia L. Newton, Michael A. Heneghan, James M. Neuberger, Darren B. Day, Samantha J. Ducker, Richard N. Sandford, Graeme J. Alexander, David E J Jones

Istituto Clinico Humanitas

Research output: Contribution to journal › Article › peer-review

Abstract

Background, & Aims: Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has precluded investigation of important disease subgroups, such as men and young patients. We used a national patient cohort to obtain a better picture of PBC phenotypes. Methods: We performed a cross-sectional study using the United Kingdom-PBC, patient cohort. Comprehensive data were collected for 2353 patients on diagnosis reports, response to therapy with ursodeoxycholic acid (UDCA), laboratory results, and symptom impact (assessed using the PBC-40 and other related measures). Results: Seventy-nine percent of the patients reported current UDCA, therapy, with 80% meeting Paris response criteria. Men were significantly less likely to have responded to UDCA than women (72% vs 80% response rate; P

Original language	English
Pages (from-to)	560-569
Number of pages	10
Journal	Gastroenterology
Volume	144
Issue number	3
DOIs	https://doi.org/10.1053/j.gastro.2012.12.005
Publication status	Published - Mar 2013

Keywords

Cirrhosis Biliary
Liver Disease
Sex
Stratified Medicine

ASJC Scopus subject areas

Gastroenterology

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10.1053/j.gastro.2012.12.005

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Carbone, M., Mells, G. F., Pells, G., Dawwas, M. F., Newton, J. L., Heneghan, M. A., Neuberger, J. M., Day, D. B., Ducker, S. J., Sandford, R. N., Alexander, G. J., & Jones, D. E. J. (2013). Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid. Gastroenterology, 144(3), 560-569. https://doi.org/10.1053/j.gastro.2012.12.005

Carbone, M, Mells, GF, Pells, G, Dawwas, MF, Newton, JL, Heneghan, MA, Neuberger, JM, Day, DB, Ducker, SJ, Sandford, RN, Alexander, GJ & Jones, DEJ 2013, 'Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid', Gastroenterology, vol. 144, no. 3, pp. 560-569. https://doi.org/10.1053/j.gastro.2012.12.005

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abstract = "Background, & Aims: Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has precluded investigation of important disease subgroups, such as men and young patients. We used a national patient cohort to obtain a better picture of PBC phenotypes. Methods: We performed a cross-sectional study using the United Kingdom-PBC, patient cohort. Comprehensive data were collected for 2353 patients on diagnosis reports, response to therapy with ursodeoxycholic acid (UDCA), laboratory results, and symptom impact (assessed using the PBC-40 and other related measures). Results: Seventy-nine percent of the patients reported current UDCA, therapy, with 80% meeting Paris response criteria. Men were significantly less likely to have responded to UDCA than women (72% vs 80% response rate; P ",

keywords = "Cirrhosis Biliary, Liver Disease, Sex, Stratified Medicine",

author = "Marco Carbone and Mells, {George F.} and Greta Pells and Dawwas, {Muhammad F.} and Newton, {Julia L.} and Heneghan, {Michael A.} and Neuberger, {James M.} and Day, {Darren B.} and Ducker, {Samantha J.} and Sandford, {Richard N.} and Alexander, {Graeme J.} and Jones, {David E J}",

year = "2013",

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doi = "10.1053/j.gastro.2012.12.005",

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AU - Carbone, Marco

AU - Mells, George F.

AU - Pells, Greta

AU - Dawwas, Muhammad F.

AU - Newton, Julia L.

AU - Heneghan, Michael A.

AU - Neuberger, James M.

AU - Day, Darren B.

AU - Ducker, Samantha J.

AU - Sandford, Richard N.

AU - Alexander, Graeme J.

AU - Jones, David E J

PY - 2013/3

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N2 - Background, & Aims: Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has precluded investigation of important disease subgroups, such as men and young patients. We used a national patient cohort to obtain a better picture of PBC phenotypes. Methods: We performed a cross-sectional study using the United Kingdom-PBC, patient cohort. Comprehensive data were collected for 2353 patients on diagnosis reports, response to therapy with ursodeoxycholic acid (UDCA), laboratory results, and symptom impact (assessed using the PBC-40 and other related measures). Results: Seventy-nine percent of the patients reported current UDCA, therapy, with 80% meeting Paris response criteria. Men were significantly less likely to have responded to UDCA than women (72% vs 80% response rate; P

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KW - Liver Disease

KW - Sex

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Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid

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Keywords

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