Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid

Marco Carbone, George F. Mells, Greta Pells, Muhammad F. Dawwas, Julia L. Newton, Michael A. Heneghan, James M. Neuberger, Darren B. Day, Samantha J. Ducker, Richard N. Sandford, Graeme J. Alexander, David E J Jones

Research output: Contribution to journalArticle

Abstract

Background, & Aims: Studies of primary biliary cirrhosis (PBC) phenotypes largely have been performed using small and selected populations. Study size has precluded investigation of important disease subgroups, such as men and young patients. We used a national patient cohort to obtain a better picture of PBC phenotypes. Methods: We performed a cross-sectional study using the United Kingdom-PBC, patient cohort. Comprehensive data were collected for 2353 patients on diagnosis reports, response to therapy with ursodeoxycholic acid (UDCA), laboratory results, and symptom impact (assessed using the PBC-40 and other related measures). Results: Seventy-nine percent of the patients reported current UDCA, therapy, with 80% meeting Paris response criteria. Men were significantly less likely to have responded to UDCA than women (72% vs 80% response rate; P

Original languageEnglish
Pages (from-to)560-569
Number of pages10
JournalGastroenterology
Volume144
Issue number3
DOIs
Publication statusPublished - Mar 2013

Keywords

  • Cirrhosis Biliary
  • Liver Disease
  • Sex
  • Stratified Medicine

ASJC Scopus subject areas

  • Gastroenterology

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    Carbone, M., Mells, G. F., Pells, G., Dawwas, M. F., Newton, J. L., Heneghan, M. A., Neuberger, J. M., Day, D. B., Ducker, S. J., Sandford, R. N., Alexander, G. J., & Jones, D. E. J. (2013). Sex and age are determinants of the clinical phenotype of primary biliary cirrhosis and response to ursodeoxycholic acid. Gastroenterology, 144(3), 560-569. https://doi.org/10.1053/j.gastro.2012.12.005