Sex- and age-related chemotherapy toxicity in patients with non-metastatic osteosarcoma

Stefano Ferrari, Emanuela Palmerini, Eric Staals, M. E. Abate, Alessandra Longhi, Marilena Cesari, A. Balladelli, Loredana Pratelli, G. Bacci

Research output: Contribution to journalArticlepeer-review


The influence of age and sex on chemotherapy-related toxicity was evaluated in children and adults with non metastatic osteosarcoma. Treatment consisted of methotrexate (MTX, 12 g/m2), cisplatin (CDP 120 mg/m2) and doxorubicin (ADM 75-90 mg/m2) and high-dose ifosfamide (HDIFO). Toxicity data from 1,051 courses (295 with MTX, 756 based on doxorubicin, cisplatin and high-dose ifosfamide) were analyzed. Children (4-14 yrs) and females showed a higher incidence of grade 4 neu-tropenia and thrombocytopenia and were more frequently hospitalized for neutropenic fever compared to adolescents and young adults (AYA, 15-19 yrs) and adults (>20-40 yrs). Delayed MTX excretion was higher in adults than AYA and children. Adults (up to 40 years) can be treated with pediatric protocols for osteosarcoma and they experience lower hematologic toxicity compared to pediatric population. Further investigations on sex-related susceptibility to chemotherapy in osteosarcoma patients are recommended.

Original languageEnglish
Pages (from-to)205-210
Number of pages6
JournalJournal of Chemotherapy
Issue number2
Publication statusPublished - Apr 1 2009


  • Adults
  • AYA
  • Chemotherapy-related toxicity
  • Children
  • Osteosarcoma
  • Sex

ASJC Scopus subject areas

  • Oncology
  • Pharmacology
  • Infectious Diseases
  • Pharmacology (medical)

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