Sex and age specificity of susceptibility genes modulating survival at old age

Giuseppe Passarino, Alberto Montesanto, Serena Dato, Sabrina Giordano, Filippo Domma, Vincenzo Mari, Emidio Feraco, Giovanna De Benedictis

Research output: Contribution to journalArticle

Abstract

Objective: We aimed to investigate the influence of the genetic variability of candidate genes on survival at old age in good health. Methods: First, on the basis of a synthetic survival curve constructed using historic mortality data taken from the Italian population from 1890 onward, we defined three age classes ranging from 18 to 106 years. Second, we assembled a multinomial logistic regression model to evaluate the effect of dichotomous variables (genotypes) on the probability to be assigned to a specific category (age class). Third, we applied the regression model to a cross-sectional dataset (10 genes; 972 subjects selected for healthy status) categorized according to age and sex. Results: We found that genetic factors influence survival at advanced age in good health in a sex- and age-specific way. Furthermore, we found that genetic variability plays a stronger role in males than in females and that, in both genders, its impact is especially important at very old ages. Conclusions: The analyses presented here underline the age-specific effect of the gene network in modulating survival at advanced age in good health.

Original languageEnglish
Pages (from-to)213-220
Number of pages8
JournalHuman Heredity
Volume62
Issue number4
DOIs
Publication statusPublished - Dec 2006

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Keywords

  • Logistic regression
  • Longevity
  • Multilocus analysis
  • Survival phenotype

ASJC Scopus subject areas

  • Genetics(clinical)

Cite this

Passarino, G., Montesanto, A., Dato, S., Giordano, S., Domma, F., Mari, V., Feraco, E., & De Benedictis, G. (2006). Sex and age specificity of susceptibility genes modulating survival at old age. Human Heredity, 62(4), 213-220. https://doi.org/10.1159/000097305