Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis

Tommaso Stroffolini, Evangelista Sagnelli, Angelo Andriulli, Guido Colloredo, Caterina Furlan, Giovanni Battista Gaeta, Filomena Morisco, Mario Pirisi, Floriano Rosina, Caterina Sagnelli, Antonina Smedile, Piero Luigi Almasio, EPACRON study group

Research output: Contribution to journalArticle

Abstract

Background: The joint effect of the interaction of alcohol intake, hepatitis B virus (HBV) and hepatitis C virus (HCV) on the risk of cirrhosis is still unexplored because a large sample size is required for this investigation. Objective: Evaluation of interaction of HBV, HCV and alcohol abuse on the risk of cirrhosis. Design: We analysed 12,262 consecutive patients with chronic liver disease of various aetiologies referring to 95 Italian liver units in 2001 or 2014. To evaluate the interaction between alcohol abuse, HBV infection, and HCV infection, patients unexposed to either factors were used as reference category. Adjustment for BMI and age was done by multiple logistic regression analysis. Results: Females were older than males (p<0.01) and less frequently showed HBV and alcoholic aetiology (p<0.01). In both sexes, an overtime increasing age and an increasing proportion of subjects with liver cirrhosis was observed, reflecting a better survival (0.01). An additive interaction is observed in females: the O.R. generated by the simultaneous presence of HBV, HCV, and alcohol (5.09; 95% C.I. 1.06–24.56) exceeds the sum (4.14) of the O.R. generated by a single exposure (O.R. = 0.72 for HBsAg positivity, OR = 1.34 for anti-HCV positivity, and O.R. = 2.08 for alcohol intake). No interaction is observed in male sex. Conclusions: The observed gender difference suggests that the simultaneous presence of HBV/HCV coinfection and risky alcohol intake enhances the mechanism of liver damage to a greater extent in females than in males.

Original languageEnglish
Article numbere0185710
JournalPLoS One
Volume12
Issue number11
DOIs
Publication statusPublished - Nov 1 2017

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Hepatitis C virus
Hepatitis B virus
Viruses
gender differences
Sex Characteristics
Hepacivirus
Fibrosis
Alcohols
alcohol abuse
Virus Diseases
Liver
Alcoholism
liver
liver cirrhosis
gender
liver diseases
Hepatitis B Surface Antigens
Coinfection
mixed infection
Liver Cirrhosis

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Stroffolini, T., Sagnelli, E., Andriulli, A., Colloredo, G., Furlan, C., Gaeta, G. B., ... EPACRON study group (2017). Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis. PLoS One, 12(11), [e0185710]. https://doi.org/10.1371/journal.pone.0185710

Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis. / Stroffolini, Tommaso; Sagnelli, Evangelista; Andriulli, Angelo; Colloredo, Guido; Furlan, Caterina; Gaeta, Giovanni Battista; Morisco, Filomena; Pirisi, Mario; Rosina, Floriano; Sagnelli, Caterina; Smedile, Antonina; Almasio, Piero Luigi; EPACRON study group.

In: PLoS One, Vol. 12, No. 11, e0185710, 01.11.2017.

Research output: Contribution to journalArticle

Stroffolini, T, Sagnelli, E, Andriulli, A, Colloredo, G, Furlan, C, Gaeta, GB, Morisco, F, Pirisi, M, Rosina, F, Sagnelli, C, Smedile, A, Almasio, PL & EPACRON study group 2017, 'Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis', PLoS One, vol. 12, no. 11, e0185710. https://doi.org/10.1371/journal.pone.0185710
Stroffolini, Tommaso ; Sagnelli, Evangelista ; Andriulli, Angelo ; Colloredo, Guido ; Furlan, Caterina ; Gaeta, Giovanni Battista ; Morisco, Filomena ; Pirisi, Mario ; Rosina, Floriano ; Sagnelli, Caterina ; Smedile, Antonina ; Almasio, Piero Luigi ; EPACRON study group. / Sex difference in the interaction of alcohol intake, hepatitis B virus, and hepatitis C virus on the risk of cirrhosis. In: PLoS One. 2017 ; Vol. 12, No. 11.
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AU - Colloredo, Guido

AU - Furlan, Caterina

AU - Gaeta, Giovanni Battista

AU - Morisco, Filomena

AU - Pirisi, Mario

AU - Rosina, Floriano

AU - Sagnelli, Caterina

AU - Smedile, Antonina

AU - Almasio, Piero Luigi

AU - EPACRON study group

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