Sex differences in effects of valsartan administration on cardiovascular outcomes in hypertensive patients: Findings from the Jikei Heart Study

Hiroshi Yoshida, Mitsuyuki Shimizu, Katsunori Ikewaki, Ikuo Taniguchi, Norio Tada, Michihiro Yoshimura, Giuseppe Rosano, Björn Dahlöf, Seibu Mochizuki

Research output: Contribution to journalArticle


Objectives: The randomized Jikei Heart Study has demonstrated that the addition of valsartan to conventional treatments prevents more cardiovascular events in Japanese patients with hypertension. This substudy analyses the sex difference in cardiovascular disease risk reduction in the Jikei Heart Study. Methods: Treatment effects were evaluated by sex (1038 women and 2043 men) as hazard ratios with 95% confidence intervals (CIs) using Cox regression models adjusted for age, BMI, smoking, dyslipidemia, diabetes, antihypertensives, and statin use at baseline. Results: Women were older, had higher SBP, total and low-density lipoprotein cholesterol but were less frequently smokers or diabetics, and had a lower DBP and incidence of coronary artery disease. A greater incidence of primary endpoint, a composite of cardiovascular events, occurred in men versus women [hazard ratio 1.37 (95% CI 1.02-1.85)]. Men in the valsartan group had a significant reduction in the primary endpoint [hazard ratio 0.6 (95% CI 0.44-0.82), P = 0.001], whereas a nonsignificant effect was found in women [hazard ratio 0.64 (95% CI 0.39-1.06), P = 0.075]. However, statistical heterogeneity of this valsartan effect was not found between sexes, and women of at least 55 years of age, mostly after menopause, in the valsartan group showed a significant risk reduction for the primary endpoint [hazard ratio 0.60 (95% CI 0.36-0.99)]. Conclusion: The valsartan effect was significant in men and in elderly women but consistent in both sexes. A potential cardiovascular protection by valsartan therapy might be attributed to the cardiovascular risk level but not to the sex difference.

Original languageEnglish
Pages (from-to)1150-1157
Number of pages8
JournalJournal of Hypertension
Issue number6
Publication statusPublished - Jun 2010



  • Angiotensin II receptor blocker
  • Cardiovascular outcomes
  • Hypertension
  • Sex
  • Valsartan

ASJC Scopus subject areas

  • Internal Medicine
  • Physiology
  • Cardiology and Cardiovascular Medicine

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