Sex differences in nevirapine disposition in HIV-infected patients

Mario Regazzi, Paola Villani, Elena Seminari, Giovanni Ravasi, Maria Cusato, Francesca Marubbi, Grazia Meneghetti, Renato Maserati

Research output: Contribution to journalArticle

Abstract

To evaluate the role of sex in nevirapine pharmacokinetics, we analysed the pharmacokinetic profile of nevirapine in 11 male and 11 female HIV-positive patients chronically treated with nevirapine 400 mg once a day. Statistically significant inter-group differences in the plasma concentration and fluctuations between that and the concentration just before the next dose, at steady-state, were observed. Variations in lean body mass and composition affecting nevirapine distribution might account for inter-sex discrepancies in nevirapine plasma levels.

Original languageEnglish
Pages (from-to)2399-2400
Number of pages2
JournalAIDS (London, England)
Volume17
Issue number16
DOIs
Publication statusPublished - Nov 7 2003

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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