Sex differences in nevirapine disposition in HIV-infected patients

Mario Regazzi, Paola Villani, Elena Seminari, Giovanni Ravasi, Maria Cusato, Francesca Marubbi, Grazia Meneghetti, Renato Maserati

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

To evaluate the role of sex in nevirapine pharmacokinetics, we analysed the pharmacokinetic profile of nevirapine in 11 male and 11 female HIV-positive patients chronically treated with nevirapine 400 mg once a day. Statistically significant inter-group differences in the plasma concentration and fluctuations between that and the concentration just before the next dose, at steady-state, were observed. Variations in lean body mass and composition affecting nevirapine distribution might account for inter-sex discrepancies in nevirapine plasma levels.

Original languageEnglish
Pages (from-to)2399-2400
Number of pages2
JournalAIDS (London, England)
Volume17
Issue number16
DOIs
Publication statusPublished - Nov 7 2003

Fingerprint

Nevirapine
Sex Characteristics
HIV
Pharmacokinetics
Body Composition

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Sex differences in nevirapine disposition in HIV-infected patients. / Regazzi, Mario; Villani, Paola; Seminari, Elena; Ravasi, Giovanni; Cusato, Maria; Marubbi, Francesca; Meneghetti, Grazia; Maserati, Renato.

In: AIDS (London, England), Vol. 17, No. 16, 07.11.2003, p. 2399-2400.

Research output: Contribution to journalArticle

@article{1fb560df2c0b4014a7ba513fee2c05be,
title = "Sex differences in nevirapine disposition in HIV-infected patients",
abstract = "To evaluate the role of sex in nevirapine pharmacokinetics, we analysed the pharmacokinetic profile of nevirapine in 11 male and 11 female HIV-positive patients chronically treated with nevirapine 400 mg once a day. Statistically significant inter-group differences in the plasma concentration and fluctuations between that and the concentration just before the next dose, at steady-state, were observed. Variations in lean body mass and composition affecting nevirapine distribution might account for inter-sex discrepancies in nevirapine plasma levels.",
author = "Mario Regazzi and Paola Villani and Elena Seminari and Giovanni Ravasi and Maria Cusato and Francesca Marubbi and Grazia Meneghetti and Renato Maserati",
year = "2003",
month = "11",
day = "7",
doi = "10.1097/00002030-200311070-00018",
language = "English",
volume = "17",
pages = "2399--2400",
journal = "AIDS",
issn = "0269-9370",
publisher = "NLM (Medline)",
number = "16",

}

TY - JOUR

T1 - Sex differences in nevirapine disposition in HIV-infected patients

AU - Regazzi, Mario

AU - Villani, Paola

AU - Seminari, Elena

AU - Ravasi, Giovanni

AU - Cusato, Maria

AU - Marubbi, Francesca

AU - Meneghetti, Grazia

AU - Maserati, Renato

PY - 2003/11/7

Y1 - 2003/11/7

N2 - To evaluate the role of sex in nevirapine pharmacokinetics, we analysed the pharmacokinetic profile of nevirapine in 11 male and 11 female HIV-positive patients chronically treated with nevirapine 400 mg once a day. Statistically significant inter-group differences in the plasma concentration and fluctuations between that and the concentration just before the next dose, at steady-state, were observed. Variations in lean body mass and composition affecting nevirapine distribution might account for inter-sex discrepancies in nevirapine plasma levels.

AB - To evaluate the role of sex in nevirapine pharmacokinetics, we analysed the pharmacokinetic profile of nevirapine in 11 male and 11 female HIV-positive patients chronically treated with nevirapine 400 mg once a day. Statistically significant inter-group differences in the plasma concentration and fluctuations between that and the concentration just before the next dose, at steady-state, were observed. Variations in lean body mass and composition affecting nevirapine distribution might account for inter-sex discrepancies in nevirapine plasma levels.

UR - http://www.scopus.com/inward/record.url?scp=0742304500&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0742304500&partnerID=8YFLogxK

U2 - 10.1097/00002030-200311070-00018

DO - 10.1097/00002030-200311070-00018

M3 - Article

VL - 17

SP - 2399

EP - 2400

JO - AIDS

JF - AIDS

SN - 0269-9370

IS - 16

ER -