Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: A population-based study from southern Italy

Davide Seripa, Marilisa Franceschi, Maria G. Matera, Francesco Panza, Patrick G. Kehoe, Carolina Gravina, Giuseppe Orsitto, Vincenzo Solfrizzi, Giovanni Di Minno, Bruno Dallapiccola, Alberto Pilotto

Research output: Contribution to journalArticlepeer-review

Abstract

We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/ε2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume61
Issue number9
Publication statusPublished - Sep 2006

ASJC Scopus subject areas

  • Ageing

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