Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: A population-based study from southern Italy

Davide Seripa, Marilisa Franceschi, Maria G. Matera, Francesco Panza, Patrick G. Kehoe, Carolina Gravina, Giuseppe Orsitto, Vincenzo Solfrizzi, Giovanni Di Minno, Bruno Dallapiccola, Alberto Pilotto

Research output: Contribution to journalArticle

Abstract

We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/ε2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.

Original languageEnglish
Pages (from-to)918-923
Number of pages6
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume61
Issue number9
Publication statusPublished - Sep 2006

Fingerprint

Apolipoproteins E
Peptidyl-Dipeptidase A
Sex Characteristics
Italy
Population
Genes
Odds Ratio
Confidence Intervals
Apolipoprotein E2
Hybrid Vigor
Logistic Models
Alleles
Genotype
Regression Analysis

ASJC Scopus subject areas

  • Ageing

Cite this

Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity : A population-based study from southern Italy. / Seripa, Davide; Franceschi, Marilisa; Matera, Maria G.; Panza, Francesco; Kehoe, Patrick G.; Gravina, Carolina; Orsitto, Giuseppe; Solfrizzi, Vincenzo; Di Minno, Giovanni; Dallapiccola, Bruno; Pilotto, Alberto.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 61, No. 9, 09.2006, p. 918-923.

Research output: Contribution to journalArticle

Seripa, Davide ; Franceschi, Marilisa ; Matera, Maria G. ; Panza, Francesco ; Kehoe, Patrick G. ; Gravina, Carolina ; Orsitto, Giuseppe ; Solfrizzi, Vincenzo ; Di Minno, Giovanni ; Dallapiccola, Bruno ; Pilotto, Alberto. / Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity : A population-based study from southern Italy. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2006 ; Vol. 61, No. 9. pp. 918-923.
@article{f4cca386410640838b25e07e94c9faec,
title = "Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity: A population-based study from southern Italy",
abstract = "We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/ε2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95{\%} confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95{\%} CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95{\%} CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.",
author = "Davide Seripa and Marilisa Franceschi and Matera, {Maria G.} and Francesco Panza and Kehoe, {Patrick G.} and Carolina Gravina and Giuseppe Orsitto and Vincenzo Solfrizzi and {Di Minno}, Giovanni and Bruno Dallapiccola and Alberto Pilotto",
year = "2006",
month = "9",
language = "English",
volume = "61",
pages = "918--923",
journal = "Journals of Gerontology - Series A Biological Sciences and Medical Sciences",
issn = "1079-5006",
publisher = "Oxford University Press",
number = "9",

}

TY - JOUR

T1 - Sex differences in the association of apolipoprotein E and angiotensin-converting enzyme gene polymorphisms with healthy aging and longevity

T2 - A population-based study from southern Italy

AU - Seripa, Davide

AU - Franceschi, Marilisa

AU - Matera, Maria G.

AU - Panza, Francesco

AU - Kehoe, Patrick G.

AU - Gravina, Carolina

AU - Orsitto, Giuseppe

AU - Solfrizzi, Vincenzo

AU - Di Minno, Giovanni

AU - Dallapiccola, Bruno

AU - Pilotto, Alberto

PY - 2006/9

Y1 - 2006/9

N2 - We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/ε2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.

AB - We investigated the association of sex and age with the occurrence of apolipoprotein E (apoE) and angiotensin-converting enzyme (ACE) genotypes in healthy aging and longevity in 1344 healthy individuals and 64 centenarians. As compared to participants younger than 60 years, a significant higher frequency of the apoE/ε2 was observed in men aged 60-90 years (p <.001) and in centenarians (p <.001). Logistic regression analysis confirmed this outcome in both participants aged 60-90 years (odds ratio [OR] = 1.897; 95% confidence interval [CI], 1.227-2.931) and centenarians (OR = 3.263; 95% CI, 1.860-5.722). A further significant association of ACE/D allele and age was observed in centenarians (OR = 2.135; 95% CI, 1.253-3.636). Heterosis was also observed at the ACE locus. No relationship between apoE and ACE polymorphism was found. These findings suggest a role of sex in the association of apoE and ACE gene polymorphisms with healthy aging and longevity.

UR - http://www.scopus.com/inward/record.url?scp=33748787154&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33748787154&partnerID=8YFLogxK

M3 - Article

C2 - 16960022

AN - SCOPUS:33748787154

VL - 61

SP - 918

EP - 923

JO - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

JF - Journals of Gerontology - Series A Biological Sciences and Medical Sciences

SN - 1079-5006

IS - 9

ER -