Sex, genes, hormones and nigral neurodegeneration: Two different Parkinson's diseases in males and in females

Sara Marceglia, Alberto Priori

Research output: Contribution to journalArticle

Abstract

Evidence from clinical, anatomical, neurophysiological, endocrinological and genetic studies demonstrates that Parkinson's disease (PD) is a gender-specific pathology. The study by Cantuti-Castelvetri et al. points out the central role of sexual dimorphisms in gene expression for understanding the pathophysiology of gender differences in PD. They identified several genes differentially expressed in female and male PD patients. Their results support the hypothesis that PD in females and in males are two different pathologies possibly associated with specific therapies. Gender differences in PD could be seen in the wider perspective of gender medicine for neurological disorders and their results suggest that basic and clinical research should examine sex differences for both understanding the disease and optimizing treatments.

Original languageEnglish
Pages (from-to)499-503
Number of pages5
JournalFuture Neurology
Volume2
Issue number5
DOIs
Publication statusPublished - Sep 2007

Keywords

  • Gender differences
  • Gene expression
  • Gonadal hormones
  • Nigral neurodegeneration
  • Parkinson's disease

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

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