In epilepsy women, sex steroid levels may be affected by seizures themselves as well as by antiepileptic drugs (AEDs).Oestradiol (E2), Progesterone (Pg), Sex Hormone Binding Globulin (SHBG) levels and calculated free E2 (fE2) were determined during the follicular and the luteal phases in 72 women with partial epilepsy, and in 30 healthy age-matched controls. Hormonal data were correlated with clinical parameters including AED regimen, and seizure frequency. No significant changes in hormone levels and ratios were observed between patient with differing seizure frequency.Women with more than two seizures per month had significantly different sex hormone levels when compared with healthy subjects; this finding could be possibly explained by the use of AED polytherapies.
|Translated title of the contribution||Sex hormone alterations in women with partial epilepsy on antiepileptic drugs: Relationships with seizure frequency and drug regimen|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 2008|
ASJC Scopus subject areas
- Clinical Neurology