Alterazioni dei livelli sierici di ormoni sessuali in donne con epilessia focale in trattamento: Relazione con frequenza delle crisi e trattamento con farmaci antiepilettici

Translated title of the contribution: Sex hormone alterations in women with partial epilepsy on antiepileptic drugs: Relationships with seizure frequency and drug regimen

C. A. Galimberti, G. Tamagno, P. Ameri, G. Ravera, S. Colnaghi, F. Magri, G. Murialdo

Research output: Contribution to journalArticle

Abstract

In epilepsy women, sex steroid levels may be affected by seizures themselves as well as by antiepileptic drugs (AEDs).Oestradiol (E2), Progesterone (Pg), Sex Hormone Binding Globulin (SHBG) levels and calculated free E2 (fE2) were determined during the follicular and the luteal phases in 72 women with partial epilepsy, and in 30 healthy age-matched controls. Hormonal data were correlated with clinical parameters including AED regimen, and seizure frequency. No significant changes in hormone levels and ratios were observed between patient with differing seizure frequency.Women with more than two seizures per month had significantly different sex hormone levels when compared with healthy subjects; this finding could be possibly explained by the use of AED polytherapies.

Original languageItalian
Pages (from-to)261-263
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number138
Publication statusPublished - 2008

Fingerprint

Partial Epilepsy
Gonadal Steroid Hormones
Anticonvulsants
Seizures
Pharmaceutical Preparations
Sex Hormone-Binding Globulin
Follicular Phase
Luteal Phase
Combination Drug Therapy
Progesterone
Estradiol
Epilepsy
Healthy Volunteers
Steroids
Hormones

ASJC Scopus subject areas

  • Clinical Neurology

Cite this

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title = "Alterazioni dei livelli sierici di ormoni sessuali in donne con epilessia focale in trattamento: Relazione con frequenza delle crisi e trattamento con farmaci antiepilettici",
abstract = "In epilepsy women, sex steroid levels may be affected by seizures themselves as well as by antiepileptic drugs (AEDs).Oestradiol (E2), Progesterone (Pg), Sex Hormone Binding Globulin (SHBG) levels and calculated free E2 (fE2) were determined during the follicular and the luteal phases in 72 women with partial epilepsy, and in 30 healthy age-matched controls. Hormonal data were correlated with clinical parameters including AED regimen, and seizure frequency. No significant changes in hormone levels and ratios were observed between patient with differing seizure frequency.Women with more than two seizures per month had significantly different sex hormone levels when compared with healthy subjects; this finding could be possibly explained by the use of AED polytherapies.",
keywords = "Antiepileptic drugs, Partial epilepsy, Sex hormones",
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TY - JOUR

T1 - Alterazioni dei livelli sierici di ormoni sessuali in donne con epilessia focale in trattamento

T2 - Relazione con frequenza delle crisi e trattamento con farmaci antiepilettici

AU - Galimberti, C. A.

AU - Tamagno, G.

AU - Ameri, P.

AU - Ravera, G.

AU - Colnaghi, S.

AU - Magri, F.

AU - Murialdo, G.

PY - 2008

Y1 - 2008

N2 - In epilepsy women, sex steroid levels may be affected by seizures themselves as well as by antiepileptic drugs (AEDs).Oestradiol (E2), Progesterone (Pg), Sex Hormone Binding Globulin (SHBG) levels and calculated free E2 (fE2) were determined during the follicular and the luteal phases in 72 women with partial epilepsy, and in 30 healthy age-matched controls. Hormonal data were correlated with clinical parameters including AED regimen, and seizure frequency. No significant changes in hormone levels and ratios were observed between patient with differing seizure frequency.Women with more than two seizures per month had significantly different sex hormone levels when compared with healthy subjects; this finding could be possibly explained by the use of AED polytherapies.

AB - In epilepsy women, sex steroid levels may be affected by seizures themselves as well as by antiepileptic drugs (AEDs).Oestradiol (E2), Progesterone (Pg), Sex Hormone Binding Globulin (SHBG) levels and calculated free E2 (fE2) were determined during the follicular and the luteal phases in 72 women with partial epilepsy, and in 30 healthy age-matched controls. Hormonal data were correlated with clinical parameters including AED regimen, and seizure frequency. No significant changes in hormone levels and ratios were observed between patient with differing seizure frequency.Women with more than two seizures per month had significantly different sex hormone levels when compared with healthy subjects; this finding could be possibly explained by the use of AED polytherapies.

KW - Antiepileptic drugs

KW - Partial epilepsy

KW - Sex hormones

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