Sex hormones, brain damage and clinical course of Multiple Sclerosis

V. Tomassini, C. Pozzilli

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

There is evidence that gender influences the clinical course of Multiple Sclerosis (MS). Symptom prevalence as well as characteristics differs between the sexes. These differences can be, at least partly, explained by gender differences in the characteristics of tissue damage and disease progression measured by Magnetic Resonance Imaging (MRI). The interaction between sex hormones and MS damage, supported by both MRI and clinical evidence, seems to play an important role in the clinical and sub-clinical gender bias in MS. Experimental data testing directly the effects of sex hormones on brain damage and their clinical relevance show that sex hormones have the potential of exerting anti-inflammatory and protective effects on brain tissue. Both data in experimental models and patient studies discussed in this review encourages a gender-based approach to MS.

Original languageEnglish
Pages (from-to)35-39
Number of pages5
JournalJournal of the Neurological Sciences
Volume286
Issue number1-2
DOIs
Publication statusPublished - Nov 15 2009

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Gonadal Steroid Hormones
Multiple Sclerosis
Brain
Magnetic Resonance Imaging
Sexism
Disease Progression
Anti-Inflammatory Agents
Theoretical Models

Keywords

  • Brain damage
  • Clinical course
  • MRI
  • Multiple Sclerosis
  • Oestrogens
  • Progesterone
  • Sex hormones
  • Testosterone

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Sex hormones, brain damage and clinical course of Multiple Sclerosis. / Tomassini, V.; Pozzilli, C.

In: Journal of the Neurological Sciences, Vol. 286, No. 1-2, 15.11.2009, p. 35-39.

Research output: Contribution to journalArticle

Tomassini, V. ; Pozzilli, C. / Sex hormones, brain damage and clinical course of Multiple Sclerosis. In: Journal of the Neurological Sciences. 2009 ; Vol. 286, No. 1-2. pp. 35-39.
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