Sex Hormones in Allergic Conjunctivitis: Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis

Marta Sacchetti, Alessandro Lambiase, Costanzo Moretti, Flavio Mantelli, Stefano Bonini

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Purpose. Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. Methods. 12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated. Results. Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P

Original languageEnglish
Article number945317
JournalJournal of Immunology Research
Volume2015
DOIs
Publication statusPublished - 2015

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Allergic Conjunctivitis
Gonadal Steroid Hormones
Androgens
Estrogens
Estrone
Testosterone
Serum
Dehydroepiandrosterone Sulfate
Androstenedione
Dihydrotestosterone
Follicle Stimulating Hormone
Puberty
Luteinizing Hormone
Hydrocortisone
Estradiol
Chronic Disease

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Sex Hormones in Allergic Conjunctivitis : Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis. / Sacchetti, Marta; Lambiase, Alessandro; Moretti, Costanzo; Mantelli, Flavio; Bonini, Stefano.

In: Journal of Immunology Research, Vol. 2015, 945317, 2015.

Research output: Contribution to journalArticle

Sacchetti, Marta ; Lambiase, Alessandro ; Moretti, Costanzo ; Mantelli, Flavio ; Bonini, Stefano. / Sex Hormones in Allergic Conjunctivitis : Altered Levels of Circulating Androgens and Estrogens in Children and Adolescents with Vernal Keratoconjunctivitis. In: Journal of Immunology Research. 2015 ; Vol. 2015.
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abstract = "Purpose. Vernal keratoconjunctivitis (VKC) is a chronic allergic disease mainly affecting boys in prepubertal age and usually recovering after puberty. To evaluate a possible role of sex hormones in VKC, serum levels of sex hormones in children and adolescents with VKC were assessed. Methods. 12 prepubertal and 7 early pubertal boys with active VKC and 6 male patients with VKC in remission phase at late pubertal age and 48 healthy age and sex-matched subjects were included. Serum concentration of estrone, 17 beta-estradiol, dehydroepiandrosterone-sulfate, total testosterone and free testosterone, dihydrotestosterone (DHT), cortisol, delta-4-androstenedione, follicle-stimulating hormone, luteinizing hormone, and sex-hormones binding globuline (SHBG) were evaluated. Results. Serum levels of Estrone were significantly increased in all groups of patients with VKC when compared to healthy controls (P",
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