Sex-specific longevity associations defined by Tyrosine Hydroxylase-Insulin-Insulin Growth Factor 2 haplotypes on the 11p15.5 chromosomal region

M. De Luca, G. Rose, M. Bonafè, S. Garasto, V. Greco, B. S. Weir, C. Franceschi, G. De Benedictis

Research output: Contribution to journalArticle

Abstract

By studies in centenarians, it was recently found that an STR marker of the Tyrosine Hydroxylase (TH, 11p15.5) gene is associated with human longevity. The aim of the present study was to continue the exploration of the 11p15.5 chromosomal region in human longevity by analyzing two additional RFLP markers, which lie in the Insulin (INS) and Insulin Growth Factor 2 (IGF2) genes. Both the genes, which are localized downstream TH, are indeed good candidates in longevity, as ascertained on the basis of laboratory studies in experimental models. Neither INS nor IGF2 markers did reveal association with longevity. Nevertheless, linkage disequilibrium analyses showed sex-specific longevity associations defined by both TH-INS and TH-IGF2 haplotypes. On the whole, the results reinforce the involvement of the chromosomal region spanning from TH to IGF2 loci in controlling the longevity phenotype in humans.

Original languageEnglish
Pages (from-to)1663-1671
Number of pages9
JournalExperimental Gerontology
Volume36
Issue number10
DOIs
Publication statusPublished - 2001

Keywords

  • Centenarians
  • IGF2 gene
  • INS gene
  • Linkage disequilibrium
  • TH gene

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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