Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus

Carla Bizzarri; Danila Benevento; Germana Giannone; Marzia Bongiovanni; Marco Anziano; Ippolita Patrizia Patera; Marco Cappa; Stefano Cianfarani

doi:10.1016/j.ghir.2014.08.004

Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus

Carla Bizzarri, Danila Benevento, Germana Giannone, Marzia Bongiovanni, Marco Anziano, Ippolita Patrizia Patera, Marco Cappa, Stefano Cianfarani

Ospedale Pediatrico Bambino Gesu

Research output: Contribution to journal › Article

Abstract

Objective: Impaired linear growth and reduced IGF-I levels in children with type 1 diabetes (T1DM) have been related to poor metabolic control. The aim of this study was to identify additional factors which may negatively affect growth and IGF system in patients with T1DM. Design: Ninety-one T1DM children (54 males, age. =.: 11.73. ±. 3. years, disease duration. =. 5.6. ±. 2.1. years) were studied. All children were on intensive insulin therapy: 62 children were on multiple injection therapy (MI) and 29 children on continuous subcutaneous insulin infusion (CSII). Results: Height velocity (HV) SDS and IGF-I levels were higher in females and in pubertal children [HV SDS: females. =. 0.6. ±. 2.4 vs males. =. -. 0.45. ±. 2.3 (. p=. 0.04); IGF-I SDS: females. =. -. 1.09. ±. 0.58 vs males. =. -. 1.4. ±. 0.6 (. p=. 0.02); IGF-I/IGFBP-3 molar ratio: females. =. 0.25. ±. 0.1 vs males. =. 0.21. ±. 0.08 (. p=. 0.04); IGF-I SDS: pre-pubertal. =. -. 1.58. ±. 0.46 vs pubertal. =. -. 1.15. ±. 0.65 (. p

Original language	English
Pages (from-to)	256-259
Number of pages	4
Journal	Growth Hormone and IGF Research
Volume	24
Issue number	6
DOIs	https://doi.org/10.1016/j.ghir.2014.08.004
Publication status	Published - Dec 1 2014

Keywords

Child
Growth
IGF-I
Type 1 diabetes

ASJC Scopus subject areas

Endocrinology
Endocrinology, Diabetes and Metabolism
Medicine(all)

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Bizzarri, C., Benevento, D., Giannone, G., Bongiovanni, M., Anziano, M., Patera, I. P., Cappa, M., & Cianfarani, S. (2014). Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus. Growth Hormone and IGF Research, 24(6), 256-259. https://doi.org/10.1016/j.ghir.2014.08.004

Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus. / Bizzarri, Carla; Benevento, Danila; Giannone, Germana; Bongiovanni, Marzia; Anziano, Marco; Patera, Ippolita Patrizia ; Cappa, Marco ; Cianfarani, Stefano.

In: Growth Hormone and IGF Research, Vol. 24, No. 6, 01.12.2014, p. 256-259.

Research output: Contribution to journal › Article

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abstract = "Objective: Impaired linear growth and reduced IGF-I levels in children with type 1 diabetes (T1DM) have been related to poor metabolic control. The aim of this study was to identify additional factors which may negatively affect growth and IGF system in patients with T1DM. Design: Ninety-one T1DM children (54 males, age. =.: 11.73. ±. 3. years, disease duration. =. 5.6. ±. 2.1. years) were studied. All children were on intensive insulin therapy: 62 children were on multiple injection therapy (MI) and 29 children on continuous subcutaneous insulin infusion (CSII). Results: Height velocity (HV) SDS and IGF-I levels were higher in females and in pubertal children [HV SDS: females. =. 0.6. ±. 2.4 vs males. =. -. 0.45. ±. 2.3 (. p=. 0.04); IGF-I SDS: females. =. -. 1.09. ±. 0.58 vs males. =. -. 1.4. ±. 0.6 (. p=. 0.02); IGF-I/IGFBP-3 molar ratio: females. =. 0.25. ±. 0.1 vs males. =. 0.21. ±. 0.08 (. p=. 0.04); IGF-I SDS: pre-pubertal. =. -. 1.58. ±. 0.46 vs pubertal. =. -. 1.15. ±. 0.65 (. p",

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AU - Bizzarri, Carla

AU - Benevento, Danila

AU - Giannone, Germana

AU - Bongiovanni, Marzia

AU - Anziano, Marco

AU - Patera, Ippolita Patrizia

AU - Cappa, Marco

AU - Cianfarani, Stefano

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N2 - Objective: Impaired linear growth and reduced IGF-I levels in children with type 1 diabetes (T1DM) have been related to poor metabolic control. The aim of this study was to identify additional factors which may negatively affect growth and IGF system in patients with T1DM. Design: Ninety-one T1DM children (54 males, age. =.: 11.73. ±. 3. years, disease duration. =. 5.6. ±. 2.1. years) were studied. All children were on intensive insulin therapy: 62 children were on multiple injection therapy (MI) and 29 children on continuous subcutaneous insulin infusion (CSII). Results: Height velocity (HV) SDS and IGF-I levels were higher in females and in pubertal children [HV SDS: females. =. 0.6. ±. 2.4 vs males. =. -. 0.45. ±. 2.3 (. p=. 0.04); IGF-I SDS: females. =. -. 1.09. ±. 0.58 vs males. =. -. 1.4. ±. 0.6 (. p=. 0.02); IGF-I/IGFBP-3 molar ratio: females. =. 0.25. ±. 0.1 vs males. =. 0.21. ±. 0.08 (. p=. 0.04); IGF-I SDS: pre-pubertal. =. -. 1.58. ±. 0.46 vs pubertal. =. -. 1.15. ±. 0.65 (. p

AB - Objective: Impaired linear growth and reduced IGF-I levels in children with type 1 diabetes (T1DM) have been related to poor metabolic control. The aim of this study was to identify additional factors which may negatively affect growth and IGF system in patients with T1DM. Design: Ninety-one T1DM children (54 males, age. =.: 11.73. ±. 3. years, disease duration. =. 5.6. ±. 2.1. years) were studied. All children were on intensive insulin therapy: 62 children were on multiple injection therapy (MI) and 29 children on continuous subcutaneous insulin infusion (CSII). Results: Height velocity (HV) SDS and IGF-I levels were higher in females and in pubertal children [HV SDS: females. =. 0.6. ±. 2.4 vs males. =. -. 0.45. ±. 2.3 (. p=. 0.04); IGF-I SDS: females. =. -. 1.09. ±. 0.58 vs males. =. -. 1.4. ±. 0.6 (. p=. 0.02); IGF-I/IGFBP-3 molar ratio: females. =. 0.25. ±. 0.1 vs males. =. 0.21. ±. 0.08 (. p=. 0.04); IGF-I SDS: pre-pubertal. =. -. 1.58. ±. 0.46 vs pubertal. =. -. 1.15. ±. 0.65 (. p

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