Abstract
Objective: Impaired linear growth and reduced IGF-I levels in children with type 1 diabetes (T1DM) have been related to poor metabolic control. The aim of this study was to identify additional factors which may negatively affect growth and IGF system in patients with T1DM. Design: Ninety-one T1DM children (54 males, age. =.: 11.73. ±. 3. years, disease duration. =. 5.6. ±. 2.1. years) were studied. All children were on intensive insulin therapy: 62 children were on multiple injection therapy (MI) and 29 children on continuous subcutaneous insulin infusion (CSII). Results: Height velocity (HV) SDS and IGF-I levels were higher in females and in pubertal children [HV SDS: females. =. 0.6. ±. 2.4 vs males. =. -. 0.45. ±. 2.3 (. p=. 0.04); IGF-I SDS: females. =. -. 1.09. ±. 0.58 vs males. =. -. 1.4. ±. 0.6 (. p=. 0.02); IGF-I/IGFBP-3 molar ratio: females. =. 0.25. ±. 0.1 vs males. =. 0.21. ±. 0.08 (. p=. 0.04); IGF-I SDS: pre-pubertal. =. -. 1.58. ±. 0.46 vs pubertal. =. -. 1.15. ±. 0.65 (. p
Original language | English |
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Pages (from-to) | 256-259 |
Number of pages | 4 |
Journal | Growth Hormone and IGF Research |
Volume | 24 |
Issue number | 6 |
DOIs | |
Publication status | Published - Dec 1 2014 |
Keywords
- Child
- Growth
- IGF-I
- Type 1 diabetes
ASJC Scopus subject areas
- Endocrinology
- Endocrinology, Diabetes and Metabolism
- Medicine(all)