Sexual dimorphism in growth and insulin-like growth factor-I in children with type 1 diabetes mellitus

Carla Bizzarri, Danila Benevento, Germana Giannone, Marzia Bongiovanni, Marco Anziano, Ippolita Patrizia Patera, Marco Cappa, Stefano Cianfarani

Research output: Contribution to journalArticle

Abstract

Objective: Impaired linear growth and reduced IGF-I levels in children with type 1 diabetes (T1DM) have been related to poor metabolic control. The aim of this study was to identify additional factors which may negatively affect growth and IGF system in patients with T1DM. Design: Ninety-one T1DM children (54 males, age. =.: 11.73. ±. 3. years, disease duration. =. 5.6. ±. 2.1. years) were studied. All children were on intensive insulin therapy: 62 children were on multiple injection therapy (MI) and 29 children on continuous subcutaneous insulin infusion (CSII). Results: Height velocity (HV) SDS and IGF-I levels were higher in females and in pubertal children [HV SDS: females. =. 0.6. ±. 2.4 vs males. =. -. 0.45. ±. 2.3 (. p=. 0.04); IGF-I SDS: females. =. -. 1.09. ±. 0.58 vs males. =. -. 1.4. ±. 0.6 (. p=. 0.02); IGF-I/IGFBP-3 molar ratio: females. =. 0.25. ±. 0.1 vs males. =. 0.21. ±. 0.08 (. p=. 0.04); IGF-I SDS: pre-pubertal. =. -. 1.58. ±. 0.46 vs pubertal. =. -. 1.15. ±. 0.65 (. p

Original languageEnglish
Pages (from-to)256-259
Number of pages4
JournalGrowth Hormone and IGF Research
Volume24
Issue number6
DOIs
Publication statusPublished - Dec 1 2014

Keywords

  • Child
  • Growth
  • IGF-I
  • Type 1 diabetes

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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