Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects

Claudia Brufani, Alberto Tozzi, Danilo Fintini, Paolo Ciampalini, Armando Grossi, Rossana Fiori, Daniela Kiepe, Melania Manco, Riccardo Schiaffini, Ottavia Porzio, Marco Cappa, Fabricio Barbetti

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Puberty is a period of rapid growth associated with metabolic, hormonal, and body composition changes that can influence risk factors for chronic diseases such as type 2 diabetes. Objective: To evaluate body composition and insulin sensitivity (IS) modifications throughout puberty in a large group of obese Caucasian subjects. Methods: Five hundred and nineteen obese subjects (4-19 years), grouped according to gender and Tanner stage (T), underwent oral glucose tolerance test. Quantitative insulin check index (QUICKI) and ISI were calculated as indexes of IS. In 309 subjects, body composition by dual-energy X-ray absorptiometry, IGF1, adiponectin, and leptin were also evaluated. Results: Body composition modifications were sexually dimorphic, with girls not modifying fat and lean percentage and fat distribution (P>0.15), and boys decreasing fat percentage and increasing lean percentage and central fat depot (P

Original languageEnglish
Pages (from-to)769-775
Number of pages7
JournalEuropean Journal of Endocrinology
Volume160
Issue number5
DOIs
Publication statusPublished - 2009

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism
  • Medicine(all)

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