TY - JOUR
T1 - Sexual dimorphism of body composition and insulin sensitivity across pubertal development in obese Caucasian subjects
AU - Brufani, Claudia
AU - Tozzi, Alberto
AU - Fintini, Danilo
AU - Ciampalini, Paolo
AU - Grossi, Armando
AU - Fiori, Rossana
AU - Kiepe, Daniela
AU - Manco, Melania
AU - Schiaffini, Riccardo
AU - Porzio, Ottavia
AU - Cappa, Marco
AU - Barbetti, Fabricio
PY - 2009
Y1 - 2009
N2 - Background: Puberty is a period of rapid growth associated with metabolic, hormonal, and body composition changes that can influence risk factors for chronic diseases such as type 2 diabetes. Objective: To evaluate body composition and insulin sensitivity (IS) modifications throughout puberty in a large group of obese Caucasian subjects. Methods: Five hundred and nineteen obese subjects (4-19 years), grouped according to gender and Tanner stage (T), underwent oral glucose tolerance test. Quantitative insulin check index (QUICKI) and ISI were calculated as indexes of IS. In 309 subjects, body composition by dual-energy X-ray absorptiometry, IGF1, adiponectin, and leptin were also evaluated. Results: Body composition modifications were sexually dimorphic, with girls not modifying fat and lean percentage and fat distribution (P>0.15), and boys decreasing fat percentage and increasing lean percentage and central fat depot (P
AB - Background: Puberty is a period of rapid growth associated with metabolic, hormonal, and body composition changes that can influence risk factors for chronic diseases such as type 2 diabetes. Objective: To evaluate body composition and insulin sensitivity (IS) modifications throughout puberty in a large group of obese Caucasian subjects. Methods: Five hundred and nineteen obese subjects (4-19 years), grouped according to gender and Tanner stage (T), underwent oral glucose tolerance test. Quantitative insulin check index (QUICKI) and ISI were calculated as indexes of IS. In 309 subjects, body composition by dual-energy X-ray absorptiometry, IGF1, adiponectin, and leptin were also evaluated. Results: Body composition modifications were sexually dimorphic, with girls not modifying fat and lean percentage and fat distribution (P>0.15), and boys decreasing fat percentage and increasing lean percentage and central fat depot (P
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U2 - 10.1530/EJE-08-0878
DO - 10.1530/EJE-08-0878
M3 - Article
C2 - 19221173
AN - SCOPUS:65549091789
VL - 160
SP - 769
EP - 775
JO - European Journal of Endocrinology
JF - European Journal of Endocrinology
SN - 0804-4643
IS - 5
ER -