Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Maria Luisa Brandi; Andrea Giustina

doi:10.1016/j.tem.2020.09.003

Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Maria Luisa Brandi, Andrea Giustina

IRCCS Ospedale San Raffaele

Research output: Contribution to journal › Review article › peer-review

Abstract

The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.

Original language	English
Pages (from-to)	918-927
Number of pages	10
Journal	Trends in Endocrinology and Metabolism
Volume	31
Issue number	12
DOIs	https://doi.org/10.1016/j.tem.2020.09.003
Publication status	Published - Dec 2020

Keywords

androgen
coronavirus disease 2019
oestrogen
pandemic
sexual dimorphism

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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10.1016/j.tem.2020.09.003

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title = "Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality",

abstract = "The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.",

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AU - Giustina, Andrea

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N2 - The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.

AB - The recent coronavirus disease 2019 (COVID-19) pandemic showed a different severity in the disease between males and females. Men have been becoming severely ill at a higher rate than women. These data along with an age-dependent disease susceptibility and mortality in the elderly suggest that sex hormones are the main factors in determining the clinical course of the infection. The differences in aging males versus females and the role of sex hormones in key phenotypes of COVID-19 infection are described in this review. Recommendations based on a dimorphic approach for males and females suggest a sex-specific management the disease.

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Sexual Dimorphism of Coronavirus 19 Morbidity and Lethality

Abstract

Keywords

ASJC Scopus subject areas

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