Abstract
Recent studies have highlighted the relation between erectile dysfunction (ED) and cardiovascular disease. In particular, the role of endothelial dysfunction and nitric oxide in ED and atherosclerotic disease has been elucidated. Given the large number of men receiving medical treatment for ED, concerns regarding the risk for sexual activity triggering acute cardiovascular events and potential risks of adverse or unanticipated drug interactions need to be addressed. A risk stratification algorithm was developed by the First Princeton Consensus Panel to evaluate the degree of cardiovascular risk associated with sexual activity for men with varying degrees of cardiovascular disease. Patients were assigned to 3 categories: low, intermediate (including those requiring further evaluation), and high risk. This consensus study from the Second Princeton Consensus Conference corroborates and clarifies the algorithm and emphasizes the importance of risk factor evaluation and management for all patients with ED. The panel reviewed recent safety and drug interaction data for 3 phosphodiesterase (PDE)-5 inhibitors (sildenafil, tadalafil, vardenafil), with emphasis on the safety of these agents in men with ED and concomitant cardiovascular disease. Increasing evidence supports the role of lifestyle intervention in ED, specifically weight loss and increased physical activity, particularly in patients with ED and concomitant cardiovascular disease. Special management recommendations for patients taking PDE-5 inhibitors who present at the emergency department and other emergency medical situations are described. Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended.
| Original language | English |
|---|---|
| Journal | The American Journal of Cardiology |
| Volume | 96 |
| Issue number | 12 SUPPL. 2 |
| DOIs | |
| Publication status | Published - Dec 26 2005 |
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ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
Sexual dysfunction and cardiac risk (The Second Princeton Consensus Conference). / Kostis, John B.; Jackson, Graham; Rosen, Raymond; Barrett-Connor, Elizabeth; Billups, Kevin; Burnett, Arthur L.; Carson, Culley; Cheitlin, Melvin; Debusk, Robert; Fonseca, Vivian; Ganz, Peter; Goldstein, Irwin; Guay, Andre; Hatzichristou, Dimitris; Hollander, Judd E.; Hutter, Adolph; Katz, Stuart; Kloner, Robert A.; Mittleman, Murray; Montorsi, Francesco; Montorsi, Piero; Nehra, Ajay; Sadovsky, Richard; Shabsigh, Ridwan.
In: The American Journal of Cardiology, Vol. 96, No. 12 SUPPL. 2, 26.12.2005.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sexual dysfunction and cardiac risk (The Second Princeton Consensus Conference)
AU - Kostis, John B.
AU - Jackson, Graham
AU - Rosen, Raymond
AU - Barrett-Connor, Elizabeth
AU - Billups, Kevin
AU - Burnett, Arthur L.
AU - Carson, Culley
AU - Cheitlin, Melvin
AU - Debusk, Robert
AU - Fonseca, Vivian
AU - Ganz, Peter
AU - Goldstein, Irwin
AU - Guay, Andre
AU - Hatzichristou, Dimitris
AU - Hollander, Judd E.
AU - Hutter, Adolph
AU - Katz, Stuart
AU - Kloner, Robert A.
AU - Mittleman, Murray
AU - Montorsi, Francesco
AU - Montorsi, Piero
AU - Nehra, Ajay
AU - Sadovsky, Richard
AU - Shabsigh, Ridwan
PY - 2005/12/26
Y1 - 2005/12/26
N2 - Recent studies have highlighted the relation between erectile dysfunction (ED) and cardiovascular disease. In particular, the role of endothelial dysfunction and nitric oxide in ED and atherosclerotic disease has been elucidated. Given the large number of men receiving medical treatment for ED, concerns regarding the risk for sexual activity triggering acute cardiovascular events and potential risks of adverse or unanticipated drug interactions need to be addressed. A risk stratification algorithm was developed by the First Princeton Consensus Panel to evaluate the degree of cardiovascular risk associated with sexual activity for men with varying degrees of cardiovascular disease. Patients were assigned to 3 categories: low, intermediate (including those requiring further evaluation), and high risk. This consensus study from the Second Princeton Consensus Conference corroborates and clarifies the algorithm and emphasizes the importance of risk factor evaluation and management for all patients with ED. The panel reviewed recent safety and drug interaction data for 3 phosphodiesterase (PDE)-5 inhibitors (sildenafil, tadalafil, vardenafil), with emphasis on the safety of these agents in men with ED and concomitant cardiovascular disease. Increasing evidence supports the role of lifestyle intervention in ED, specifically weight loss and increased physical activity, particularly in patients with ED and concomitant cardiovascular disease. Special management recommendations for patients taking PDE-5 inhibitors who present at the emergency department and other emergency medical situations are described. Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended.
AB - Recent studies have highlighted the relation between erectile dysfunction (ED) and cardiovascular disease. In particular, the role of endothelial dysfunction and nitric oxide in ED and atherosclerotic disease has been elucidated. Given the large number of men receiving medical treatment for ED, concerns regarding the risk for sexual activity triggering acute cardiovascular events and potential risks of adverse or unanticipated drug interactions need to be addressed. A risk stratification algorithm was developed by the First Princeton Consensus Panel to evaluate the degree of cardiovascular risk associated with sexual activity for men with varying degrees of cardiovascular disease. Patients were assigned to 3 categories: low, intermediate (including those requiring further evaluation), and high risk. This consensus study from the Second Princeton Consensus Conference corroborates and clarifies the algorithm and emphasizes the importance of risk factor evaluation and management for all patients with ED. The panel reviewed recent safety and drug interaction data for 3 phosphodiesterase (PDE)-5 inhibitors (sildenafil, tadalafil, vardenafil), with emphasis on the safety of these agents in men with ED and concomitant cardiovascular disease. Increasing evidence supports the role of lifestyle intervention in ED, specifically weight loss and increased physical activity, particularly in patients with ED and concomitant cardiovascular disease. Special management recommendations for patients taking PDE-5 inhibitors who present at the emergency department and other emergency medical situations are described. Finally, further research on the role of PDE-5 inhibition in treating patients with other medical or cardiovascular disorders is recommended.
UR - http://www.scopus.com/inward/record.url?scp=29544443156&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=29544443156&partnerID=8YFLogxK
U2 - 10.1016/j.amjcard.2005.12.018
DO - 10.1016/j.amjcard.2005.12.018
M3 - Article
C2 - 16387575
AN - SCOPUS:29544443156
VL - 96
JO - American Journal of Cardiology
JF - American Journal of Cardiology
SN - 0002-9149
IS - 12 SUPPL. 2
ER -