Sexual dysfunction in multiple sclerosis: A MRI, neurophysiological and urodynamic study

Robert Zivadinov, Marino Zorzon, Laura Locatelli, Barbara Stival, Fabrizio Monti, Davide Nasuelli, Maria Antonietta Tommasi, Alessio Bratina, Giuseppe Cazzato

Research output: Contribution to journalArticlepeer-review


We studied 31 patients with relapsing-remitting (RR) multiple sclerosis (MS) in which we performed an urodynamic study, the pudendal cortical evoked potentials, the tibial cortical evoked potentials and the cranial and cervical spinal cord magnetic resonance imaging (MRI). We calculated the T1 and T2 lesion load (LL) and brain parenchymal fraction (BPF) of whole brain, frontal lobes, pons and cervical spinal cord. We also estimated the cross-sectional area at C2 level. Spearman's rank correlation analysis showed a relationship between symptoms of sexual dysfunction and age (r=0.73, p1 lesion load of the pons. In conclusion, we confirmed previous correlations of sexual dysfunction with various clinical variables and demonstrated an association between sexual dysfunction and destructive lesions in the pons, as detected by MRI, in patients with relapsing-remitting multiple sclerosis.

Original languageEnglish
Pages (from-to)73-76
Number of pages4
JournalJournal of the Neurological Sciences
Issue number1-2
Publication statusPublished - Jun 15 2003


  • MRI
  • Multiple sclerosis
  • Neurophysiological study
  • Sexual dysfunction
  • Sphincteric dysfunction
  • Urodynamic study

ASJC Scopus subject areas

  • Ageing
  • Clinical Neurology
  • Surgery
  • Neuroscience(all)
  • Developmental Neuroscience
  • Neurology

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