Sexual function in hypertensive males treated with lisinopril or atenolol: A cross-over study

Roberto Fogari, Annalisa Zoppi, Luca Corradi, Amedeo Mugellini, Luigi Poletti, Paola Lusardi

Research output: Contribution to journalArticle


To evaluate the effect of antihypertensive treatment on sexual activity, 90 hypertensive men, aged 40 to 49 years, all married and without history of sexual dysfunction were treated with 100 mg of atenolol or 20 mg of lisinopril for 16 weeks, according to a double-blind, randomized, crossover design. During the first month of therapy, sexual activity, assessed as number of sexual intercourse episodes per month, significantly declined with both atenolol (from 7.8 ± 4.3 to 4.5 ± 2.8, P <.01 v placebo) and lisinopril (from 7.1 ± 4.0 to 5.0 ± 2.5, P <.05 v placebo). Ongoing with the treatment, sexual activity tended toward recovery in the lisinopril (7.7 ± 4.0 sexual intercourse episodes per month, P = NS v placebo), but not in the atenolol group (4.2 ± 2.8, P <.01 v placebo), with a statistically significant difference between the two drugs (P <.01). The percentage of patients who complained of sexual dysfunction symptoms was significantly higher in the atenolol- than in the lisinopril-treated group (17% v 3%, P <.05). These findings suggest that atenolol induces a chronic worsening of sexual activity, whereas lisinopril causes only a temporary decline.

Original languageEnglish
Pages (from-to)1244-1247
Number of pages4
JournalAmerican Journal of Hypertension
Issue number10 I
Publication statusPublished - Oct 1998


  • Atenolol
  • Hypertension
  • Lisinopril
  • Sexual activity

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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