Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease

Giampiero Palladino, Vincenzina Nicolia, Gabor G. Kovacs, Sonia Canterini, Viviana Ciraci, Andrea Fuso, Franco Mangia, Sigfrido Scarpa, Maria Teresa Fiorenza

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Molecular Neuroscience
DOIs
Publication statusAccepted/In press - Nov 19 2016

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Alzheimer Disease
Sex Factors
Amyloid beta-Protein Precursor
Brain
Amyloidosis
Amyloid
Down-Regulation
Cognitive Dysfunction

Keywords

  • Aβ-plaques
  • Mouse models of AD
  • Sex-influenced gene expression patterns
  • TgCRND8

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

Cite this

Palladino, G., Nicolia, V., Kovacs, G. G., Canterini, S., Ciraci, V., Fuso, A., ... Fiorenza, M. T. (Accepted/In press). Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. Journal of Molecular Neuroscience, 1-9. https://doi.org/10.1007/s12031-016-0865-x

Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. / Palladino, Giampiero; Nicolia, Vincenzina; Kovacs, Gabor G.; Canterini, Sonia; Ciraci, Viviana; Fuso, Andrea; Mangia, Franco; Scarpa, Sigfrido; Fiorenza, Maria Teresa.

In: Journal of Molecular Neuroscience, 19.11.2016, p. 1-9.

Research output: Contribution to journalArticle

Palladino, G, Nicolia, V, Kovacs, GG, Canterini, S, Ciraci, V, Fuso, A, Mangia, F, Scarpa, S & Fiorenza, MT 2016, 'Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease', Journal of Molecular Neuroscience, pp. 1-9. https://doi.org/10.1007/s12031-016-0865-x
Palladino, Giampiero ; Nicolia, Vincenzina ; Kovacs, Gabor G. ; Canterini, Sonia ; Ciraci, Viviana ; Fuso, Andrea ; Mangia, Franco ; Scarpa, Sigfrido ; Fiorenza, Maria Teresa. / Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. In: Journal of Molecular Neuroscience. 2016 ; pp. 1-9.
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