Abstract
Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
| Original language | English |
|---|---|
| Pages (from-to) | 1-9 |
| Number of pages | 9 |
| Journal | Journal of Molecular Neuroscience |
| DOIs | |
| Publication status | Accepted/In press - Nov 19 2016 |
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Keywords
- Aβ-plaques
- Mouse models of AD
- Sex-influenced gene expression patterns
- TgCRND8
ASJC Scopus subject areas
- Cellular and Molecular Neuroscience
Cite this
Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. / Palladino, Giampiero; Nicolia, Vincenzina; Kovacs, Gabor G.; Canterini, Sonia; Ciraci, Viviana; Fuso, Andrea; Mangia, Franco; Scarpa, Sigfrido; Fiorenza, Maria Teresa.
In: Journal of Molecular Neuroscience, 19.11.2016, p. 1-9.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease
AU - Palladino, Giampiero
AU - Nicolia, Vincenzina
AU - Kovacs, Gabor G.
AU - Canterini, Sonia
AU - Ciraci, Viviana
AU - Fuso, Andrea
AU - Mangia, Franco
AU - Scarpa, Sigfrido
AU - Fiorenza, Maria Teresa
PY - 2016/11/19
Y1 - 2016/11/19
N2 - Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
AB - Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.
KW - Aβ-plaques
KW - Mouse models of AD
KW - Sex-influenced gene expression patterns
KW - TgCRND8
UR - http://www.scopus.com/inward/record.url?scp=84995814984&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84995814984&partnerID=8YFLogxK
U2 - 10.1007/s12031-016-0865-x
DO - 10.1007/s12031-016-0865-x
M3 - Article
AN - SCOPUS:84995814984
SP - 1
EP - 9
JO - Journal of Molecular Neuroscience
JF - Journal of Molecular Neuroscience
SN - 0895-8696
ER -