Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease

Giampiero Palladino, Vincenzina Nicolia, Gabor G. Kovacs, Sonia Canterini, Viviana Ciraci, Andrea Fuso, Franco Mangia, Sigfrido Scarpa, Maria Teresa Fiorenza

Research output: Contribution to journalArticlepeer-review

Abstract

Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.

Original languageEnglish
Pages (from-to)1-9
Number of pages9
JournalJournal of Molecular Neuroscience
DOIs
Publication statusAccepted/In press - Nov 19 2016

Keywords

  • Aβ-plaques
  • Mouse models of AD
  • Sex-influenced gene expression patterns
  • TgCRND8

ASJC Scopus subject areas

  • Cellular and Molecular Neuroscience

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