Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease

Giampiero Palladino; Vincenzina Nicolia; Gabor G. Kovacs; Sonia Canterini; Viviana Ciraci; Andrea Fuso; Franco Mangia; Sigfrido Scarpa; Maria Teresa Fiorenza

doi:10.1007/s12031-016-0865-x

Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease

Giampiero Palladino, Vincenzina Nicolia, Gabor G. Kovacs, Sonia Canterini, Viviana Ciraci, Andrea Fuso, Franco Mangia, Sigfrido Scarpa, Maria Teresa Fiorenza

Fondazione Santa Lucia

Research output: Contribution to journal › Article › peer-review

Abstract

Recent evidence highlights the protective role of reelin against amyloid β (Aβ)-induced synaptic dysfunction and cognitive impairment in Alzheimer disease (AD). In this study, exploiting TgCRND8 mice that overexpress a mutant form of amyloid β precursor protein (AβPP) and display an early onset of AD neuropathological signs, we addressed the question whether changes of reelin expression eventually precede the appearance of Aβ-plaques in a sex-dependent manner. We show that sex-associated and brain region-specific differences in reelin expression appear long before Aβ-plaque formation. However, in spite of a downregulation of reelin expression compared to males, TgCRND8 females display fewer Aβ-plaques, suggesting that additional factors, other than sex and reelin level, influence amyloidosis in this mouse model.

Original language	English
Pages (from-to)	1-9
Number of pages	9
Journal	Journal of Molecular Neuroscience
DOIs	https://doi.org/10.1007/s12031-016-0865-x
Publication status	Accepted/In press - Nov 19 2016

Keywords

Aβ-plaques
Mouse models of AD
Sex-influenced gene expression patterns
TgCRND8

ASJC Scopus subject areas

Cellular and Molecular Neuroscience

Access to Document

10.1007/s12031-016-0865-x

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Sexually Dimorphic Expression of Reelin in the Brain of a Mouse Model of Alzheimer Disease. / Palladino, Giampiero; Nicolia, Vincenzina; Kovacs, Gabor G.; Canterini, Sonia; Ciraci, Viviana; Fuso, Andrea; Mangia, Franco; Scarpa, Sigfrido; Fiorenza, Maria Teresa.

In: Journal of Molecular Neuroscience, 19.11.2016, p. 1-9.

Research output: Contribution to journal › Article › peer-review

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AU - Mangia, Franco

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