Shape of the OGTT glucose curve and risk of impaired glucose metabolism in the EGIR-RISC cohort

M Manco, G Nolfe, Z Pataky, L Monti, F Porcellati, R Gabriel, A Mitrakou, G Mingrone

Research output: Contribution to journalArticlepeer-review

Abstract

Objective To study whether the shape of the oral glucose tolerance test (OGTT)-glucose curve is a stable trait over time; it is associated with differences in insulin sensitivity, ß-cell function and risk of impaired fasting glucose (IFG) and glucose tolerance (IGT) in the Relationship between Insulin Sensitivity and Cardiovascular Disease (RISC) cohort. Methods OGTT-glucose curve shape was classified as monophasic, biphasic, triphasic and anomalous in 915 individuals. Oral glucose insulin sensitivity (OGIS), Matsuda insulin sensitivity index (ISI) and ß-cell function were assessed at baseline and 3 years apart. Results The OGTT-glucose curve had the same baseline shape after 3 years in 540 people (59%; κ = 0.115; p 
Original languageEnglish
Pages (from-to)42-50
Number of pages9
JournalMetabolism: Clinical and Experimental
Volume70
Issue number2
DOIs
Publication statusPublished - 2017

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