Shaping excitation at glutamatergic synapses

Fiorenzo Conti, Richard J. Weinberg

Research output: Contribution to journalArticlepeer-review


Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.

Original languageEnglish
Pages (from-to)451-458
Number of pages8
JournalTrends in Neurosciences
Issue number10
Publication statusPublished - Oct 1999

ASJC Scopus subject areas

  • Neuroscience(all)


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