TY - JOUR
T1 - Shaping excitation at glutamatergic synapses
AU - Conti, Fiorenzo
AU - Weinberg, Richard J.
PY - 1999/10
Y1 - 1999/10
N2 - Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.
AB - Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.
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UR - http://www.scopus.com/inward/citedby.url?scp=0033215089&partnerID=8YFLogxK
U2 - 10.1016/S0166-2236(99)01445-9
DO - 10.1016/S0166-2236(99)01445-9
M3 - Article
C2 - 10481192
AN - SCOPUS:0033215089
VL - 22
SP - 451
EP - 458
JO - Trends in Neurosciences
JF - Trends in Neurosciences
SN - 0378-5912
IS - 10
ER -