Shaping excitation at glutamatergic synapses

Fiorenzo Conti; Richard J. Weinberg

doi:10.1016/S0166-2236(99)01445-9

Shaping excitation at glutamatergic synapses

Fiorenzo Conti, Richard J. Weinberg

Istituto Nazionale di Riposo e Cura per Anziani V.E. II

Research output: Contribution to journal › Article

Abstract

Glutamatergic synapses vary, exhibiting EPSCs of widely different magnitudes and timecourses. The main contributors to this variability are: presynaptic factors, including release probability, quantal content and vesicle composition; factors that modulate the concentration and longevity of glutamate in the cleft, including diffusion and the actions of glutamate transporters; and postsynaptic factors, including the types and locations of ionotropic glutamate receptors, their numbers, and the nature and locations of associated intracellular signalling systems.

Original language	English
Pages (from-to)	451-458
Number of pages	8
Journal	Trends in Neurosciences
Volume	22
Issue number	10
DOIs	https://doi.org/10.1016/S0166-2236(99)01445-9
Publication status	Published - Oct 1999

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ASJC Scopus subject areas

Neuroscience(all)

Cite this

Conti, F., & Weinberg, R. J. (1999). Shaping excitation at glutamatergic synapses. Trends in Neurosciences, 22(10), 451-458. https://doi.org/10.1016/S0166-2236(99)01445-9

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10.1016/S0166-2236(99)01445-9