Shaping the excitability of human motor cortex with premotor rTMS

Vincenzo Rizzo, Hartwig R. Siebner, Nicola Modugno, Alessandra Pesenti, Alexander Münchau, Willibald Gerschlager, Ruth M. Webb, John C. Rothwell

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Abstract

Recent studies have shown that low-frequency repetitive transcranial magnetic stimulation (rTMS) to the left dorsal premotor cortex has a lasting influence on the excitability of specific neuronal subpopulations in the ipsilateral primary motor hand area (M1HAND). Here we asked how these premotor to motor interactions are shaped by the intensity and frequency of rTMS and the orientation of the stimulating coil. We confirmed that premotor rTMS at 1 Hz and an intensity of 90% active motor threshold (AMT) produced a lasting decrease in corticospinal excitability probed with single-pulse TMS over the left M1HAND. Reducing the intensity to 80% AMT increased paired-pulse excitability at an interstimulus interval (ISI) of 7 ms. Opposite effects occurred if rTMS was given at 5 Hz: at 90% AMT, corticospinal excitability increased; at 80% AMT, paired-pulse excitability at ISI = 7 ms decreased. No effects were seen if rTMS was applied at the same intensities to prefrontal or primary motor cortices. These findings indicate that the intensity of premotor rTMS determines the net effect of conditioning on distinct populations of neurones in the ipsilateral M1HAND, but it is the frequency of rTMS that determines the direction of the induced change. By selecting the appropriate intensity and frequency, premotor rTMS allows to induce a predictable up- or down-regulation of the excitability in distinct neuronal circuits of human M1HAND.

Original languageEnglish
Pages (from-to)483-495
Number of pages13
JournalJournal of Physiology
Volume554
Issue number2
DOIs
Publication statusPublished - Jan 15 2004

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Transcranial Magnetic Stimulation
Motor Cortex
Up-Regulation
Down-Regulation
Hand
Neurons

ASJC Scopus subject areas

  • Physiology

Cite this

Rizzo, V., Siebner, H. R., Modugno, N., Pesenti, A., Münchau, A., Gerschlager, W., ... Rothwell, J. C. (2004). Shaping the excitability of human motor cortex with premotor rTMS. Journal of Physiology, 554(2), 483-495. https://doi.org/10.1113/jphysiol.2003.048777

Shaping the excitability of human motor cortex with premotor rTMS. / Rizzo, Vincenzo; Siebner, Hartwig R.; Modugno, Nicola; Pesenti, Alessandra; Münchau, Alexander; Gerschlager, Willibald; Webb, Ruth M.; Rothwell, John C.

In: Journal of Physiology, Vol. 554, No. 2, 15.01.2004, p. 483-495.

Research output: Contribution to journalArticle

Rizzo, V, Siebner, HR, Modugno, N, Pesenti, A, Münchau, A, Gerschlager, W, Webb, RM & Rothwell, JC 2004, 'Shaping the excitability of human motor cortex with premotor rTMS', Journal of Physiology, vol. 554, no. 2, pp. 483-495. https://doi.org/10.1113/jphysiol.2003.048777
Rizzo V, Siebner HR, Modugno N, Pesenti A, Münchau A, Gerschlager W et al. Shaping the excitability of human motor cortex with premotor rTMS. Journal of Physiology. 2004 Jan 15;554(2):483-495. https://doi.org/10.1113/jphysiol.2003.048777
Rizzo, Vincenzo ; Siebner, Hartwig R. ; Modugno, Nicola ; Pesenti, Alessandra ; Münchau, Alexander ; Gerschlager, Willibald ; Webb, Ruth M. ; Rothwell, John C. / Shaping the excitability of human motor cortex with premotor rTMS. In: Journal of Physiology. 2004 ; Vol. 554, No. 2. pp. 483-495.
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