Shaping the gradient by nonchemotactic chemokine receptors

Elena Monica Borroni, Raffaella Bonecchi

Research output: Contribution to journalArticlepeer-review

Abstract

Chemokines are a class of inflammatory mediators which main function is to direct leukocyte migration through the binding to G protein-coupled receptors (GPCRs). In addition to these functional, signal-transducing chemokine receptors other types of receptors belonging to the chemokine GPCR family were identified. They are called atypical or decoy chemokine receptors because they bind and degrade chemokines but do not transduce signals or activate cell migration. Here there is the summary of two recent papers that identified other nonchemotactic chemokine receptors: the Duffy antigen receptor for chemokines (DARC) that mediates trancytosis of chemokines from tissue to vascular lumen promoting chemokine-mediated leukocyte transmigration and chemokine (CC motif) receptor-like 2 (CCRL2) that neither internalizes its ligands nor transduces signals but presents bound ligands to functional signaling receptors improving their activity. Collectively these nonchemotactic chemokine receptors do not directly induce cell migration, but appear nonetheless to play a nonredundant role in leukocyte recruitment by shaping the chemoattractant gradient, either by removing, transporting or concentrating their cognate ligands.

Original languageEnglish
Pages (from-to)146-147
Number of pages2
JournalCell Adhesion and Migration
Volume3
Issue number2
DOIs
Publication statusPublished - Apr 2009

Keywords

  • Chemokine
  • Chemokine receptor
  • Chemotaxis
  • Leukocyte recruitment
  • Transcytosis

ASJC Scopus subject areas

  • Cell Biology
  • Cellular and Molecular Neuroscience

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