Abstract
Background and Purpose-Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Methods-Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genomewide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P
Original language | English |
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Pages (from-to) | 24-36 |
Number of pages | 13 |
Journal | Stroke |
Volume | 45 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Keywords
- Coronary artery disease
- Genetics
- Meta-analysis
- Polymorphism
- Single nucleotide
- Stroke
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
- Clinical Neurology
- Advanced and Specialised Nursing