Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants

Martin Dichgans; Rainer Malik; Inke R. König; Jonathan Rosand; Robert Clarke; Solveig Gretarsdottir; Gudmar Thorleifsson; Braxton D. Mitchell; Themistocles L. Assimes; Christopher Levi; Christopher J. Ódonnell; Myriam Fornage; Unnur Thorsteinsdottir; Bruce M. Psaty; Christian Hengstenberg; Sudha Seshadri; Jeanette Erdmann; Joshua C. Bis; Annette Peters; Giorgio B. Boncoraglio; Winfried März; James F. Meschia; Sekar Kathiresan; M. Arfan Ikram; Ruth McPherson; Kari Stefansson; Cathie Sudlow; Muredach P. Reilly; John R. Thompson; Pankaj Sharma; Jemma C. Hopewell; John C. Chambers; Hugh Watkins; Peter M. Rothwell; Robert Roberts; Hugh S. Markus; Nilesh J. Samani; Martin Farrall; Heribert Schunkert

doi:10.1161/STROKEAHA.113.002707

Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants

Martin Dichgans, Rainer Malik, Inke R. König, Jonathan Rosand, Robert Clarke, Solveig Gretarsdottir, Gudmar Thorleifsson, Braxton D. Mitchell, Themistocles L. Assimes, Christopher Levi, Christopher J. Ódonnell, Myriam Fornage, Unnur Thorsteinsdottir, Bruce M. Psaty, Christian Hengstenberg, Sudha Seshadri, Jeanette Erdmann, Joshua C. Bis, Annette Peters, Giorgio B. BoncoraglioWinfried März, James F. Meschia, Sekar Kathiresan, M. Arfan Ikram, Ruth McPherson, Kari Stefansson, Cathie Sudlow, Muredach P. Reilly, John R. Thompson, Pankaj Sharma, Jemma C. Hopewell, John C. Chambers, Hugh Watkins, Peter M. Rothwell, Robert Roberts, Hugh S. Markus, Nilesh J. Samani, Martin Farrall, Heribert Schunkert

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Background and Purpose-Ischemic stroke (IS) and coronary artery disease (CAD) share several risk factors and each has a substantial heritability. We conducted a genome-wide analysis to evaluate the extent of shared genetic determination of the two diseases. Methods-Genome-wide association data were obtained from the METASTROKE, Coronary Artery Disease Genomewide Replication and Meta-analysis (CARDIoGRAM), and Coronary Artery Disease (C4D) Genetics consortia. We first analyzed common variants reaching a nominal threshold of significance (P

Original language	English
Pages (from-to)	24-36
Number of pages	13
Journal	Stroke
Volume	45
Issue number	1
DOIs	https://doi.org/10.1161/STROKEAHA.113.002707
Publication status	Published - Jan 2014

Keywords

Coronary artery disease
Genetics
Meta-analysis
Polymorphism
Single nucleotide
Stroke

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine
Clinical Neurology
Advanced and Specialised Nursing

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Dichgans, M., Malik, R., König, I. R., Rosand, J., Clarke, R., Gretarsdottir, S., Thorleifsson, G., Mitchell, B. D., Assimes, T. L., Levi, C., Ódonnell, C. J., Fornage, M., Thorsteinsdottir, U., Psaty, B. M., Hengstenberg, C., Seshadri, S., Erdmann, J., Bis, J. C., Peters, A., ... Schunkert, H. (2014). Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants. Stroke, 45(1), 24-36. https://doi.org/10.1161/STROKEAHA.113.002707

Shared genetic susceptibility to ischemic stroke and coronary artery disease : A genome-wide analysis of common variants. / Dichgans, Martin; Malik, Rainer; König, Inke R.; Rosand, Jonathan; Clarke, Robert; Gretarsdottir, Solveig; Thorleifsson, Gudmar; Mitchell, Braxton D.; Assimes, Themistocles L.; Levi, Christopher; Ódonnell, Christopher J.; Fornage, Myriam; Thorsteinsdottir, Unnur; Psaty, Bruce M.; Hengstenberg, Christian; Seshadri, Sudha; Erdmann, Jeanette; Bis, Joshua C.; Peters, Annette; Boncoraglio, Giorgio B.; März, Winfried; Meschia, James F.; Kathiresan, Sekar; Ikram, M. Arfan; McPherson, Ruth; Stefansson, Kari; Sudlow, Cathie; Reilly, Muredach P.; Thompson, John R.; Sharma, Pankaj; Hopewell, Jemma C.; Chambers, John C.; Watkins, Hugh; Rothwell, Peter M.; Roberts, Robert; Markus, Hugh S.; Samani, Nilesh J.; Farrall, Martin; Schunkert, Heribert.

In: Stroke, Vol. 45, No. 1, 01.2014, p. 24-36.

Research output: Contribution to journal › Article › peer-review

Dichgans, M, Malik, R, König, IR, Rosand, J, Clarke, R, Gretarsdottir, S, Thorleifsson, G, Mitchell, BD, Assimes, TL, Levi, C, Ódonnell, CJ, Fornage, M, Thorsteinsdottir, U, Psaty, BM, Hengstenberg, C, Seshadri, S, Erdmann, J, Bis, JC, Peters, A, Boncoraglio, GB, März, W, Meschia, JF, Kathiresan, S, Ikram, MA, McPherson, R, Stefansson, K, Sudlow, C, Reilly, MP, Thompson, JR, Sharma, P, Hopewell, JC, Chambers, JC, Watkins, H, Rothwell, PM, Roberts, R, Markus, HS, Samani, NJ, Farrall, M & Schunkert, H 2014, 'Shared genetic susceptibility to ischemic stroke and coronary artery disease: A genome-wide analysis of common variants', Stroke, vol. 45, no. 1, pp. 24-36. https://doi.org/10.1161/STROKEAHA.113.002707

Dichgans, Martin ; Malik, Rainer ; König, Inke R. ; Rosand, Jonathan ; Clarke, Robert ; Gretarsdottir, Solveig ; Thorleifsson, Gudmar ; Mitchell, Braxton D. ; Assimes, Themistocles L. ; Levi, Christopher ; Ódonnell, Christopher J. ; Fornage, Myriam ; Thorsteinsdottir, Unnur ; Psaty, Bruce M. ; Hengstenberg, Christian ; Seshadri, Sudha ; Erdmann, Jeanette ; Bis, Joshua C. ; Peters, Annette ; Boncoraglio, Giorgio B. ; März, Winfried ; Meschia, James F. ; Kathiresan, Sekar ; Ikram, M. Arfan ; McPherson, Ruth ; Stefansson, Kari ; Sudlow, Cathie ; Reilly, Muredach P. ; Thompson, John R. ; Sharma, Pankaj ; Hopewell, Jemma C. ; Chambers, John C. ; Watkins, Hugh ; Rothwell, Peter M. ; Roberts, Robert ; Markus, Hugh S. ; Samani, Nilesh J. ; Farrall, Martin ; Schunkert, Heribert. / Shared genetic susceptibility to ischemic stroke and coronary artery disease : A genome-wide analysis of common variants. In: Stroke. 2014 ; Vol. 45, No. 1. pp. 24-36.

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