Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging

Anne C. Hofer, Rosie T. Tran, Owais Z. Aziz, Woodring Wright, Giuseppe Novelli, Jerry Shay, Marc Lewis

Research output: Contribution to journalArticle

47 Citations (Scopus)

Abstract

Segmental progeroid syndromes are those whose phenotypes resemble accelerated aging. Here we analyze those phenotypes and hypothesize that short telomeres produce the same group of symptoms in a variety of otherwise unrelated progeroid syndromes. Specific findings are the following: (a) short telomeres in some progeroid syndromes cause an alopecia/osteoporosis/ fingernail-atrophy group of symptoms; (b) fingernail atrophy in progeroid syndromes resembles the natural slowing of nail growth that occurs in normal aging and nail growth velocity, and may be a marker of replicative aging in keratinocyte stem cells; (c) alopecia and reduced hair diameter parallel the nail results; (d) osteoporosis in Dyskeratosis Congenita resembles age-related osteoporosis, but the same is not true of other progerias; and (e) gray hair is associated with short telomeres, but may also involve reactive oxygen species. On the basis of these results, we make several predictions and discuss how the segmental quality of progeroid syndromes may provide insight into normative aging.

Original languageEnglish
Pages (from-to)10-20
Number of pages11
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume60
Issue number1
Publication statusPublished - Jan 2005

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Nails
Telomere
Phenotype
Osteoporosis
Alopecia
Hair
Atrophy
Dyskeratosis Congenita
Growth
Keratinocytes
Reactive Oxygen Species
Stem Cells

ASJC Scopus subject areas

  • Ageing

Cite this

Hofer, A. C., Tran, R. T., Aziz, O. Z., Wright, W., Novelli, G., Shay, J., & Lewis, M. (2005). Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging. Journals of Gerontology - Series A Biological Sciences and Medical Sciences, 60(1), 10-20.

Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging. / Hofer, Anne C.; Tran, Rosie T.; Aziz, Owais Z.; Wright, Woodring; Novelli, Giuseppe; Shay, Jerry; Lewis, Marc.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 60, No. 1, 01.2005, p. 10-20.

Research output: Contribution to journalArticle

Hofer, AC, Tran, RT, Aziz, OZ, Wright, W, Novelli, G, Shay, J & Lewis, M 2005, 'Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging', Journals of Gerontology - Series A Biological Sciences and Medical Sciences, vol. 60, no. 1, pp. 10-20.
Hofer, Anne C. ; Tran, Rosie T. ; Aziz, Owais Z. ; Wright, Woodring ; Novelli, Giuseppe ; Shay, Jerry ; Lewis, Marc. / Shared phenotypes among segmental progeroid syndromes suggest underlying pathways of aging. In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences. 2005 ; Vol. 60, No. 1. pp. 10-20.
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