Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

Alzheimer’s Disease Neuroimaging Initiative

Research output: Contribution to journalArticle

Abstract

Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.

Original languageEnglish
JournalNature Human Behaviour
DOIs
Publication statusPublished - Jan 1 2019

Fingerprint

Connectome
Brain Diseases
Nervous System Diseases
Psychiatry
Brain
Communication
Dermatoglyphics

ASJC Scopus subject areas

  • Social Psychology
  • Experimental and Cognitive Psychology
  • Behavioral Neuroscience

Cite this

Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders. / Alzheimer’s Disease Neuroimaging Initiative.

In: Nature Human Behaviour, 01.01.2019.

Research output: Contribution to journalArticle

@article{fe56409233594369956804845f2a32c1,
title = "Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders",
abstract = "Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.",
author = "{Alzheimer’s Disease Neuroimaging Initiative} and {de Lange}, {Siemon C.} and Scholtens, {Lianne H.} and {van den Berg}, {Leonard H.} and Boks, {Marco P.} and Marco Bozzali and Wiepke Cahn and Udo Dannlowski and Sarah Durston and Elbert Geuze and {van Haren}, {Neeltje E.M.} and Hillegers, {Manon H.J.} and Kathrin Koch and Jurado, {Mar{\'i}a {\'A}ngeles} and Matteo Mancini and Idoia Marqu{\'e}s-Iturria and Susanne Meinert and Ophoff, {Roel A.} and Reess, {Tim J.} and Jonathan Repple and Kahn, {Ren{\'e} S.} and {van den Heuvel}, {Martijn P.}",
year = "2019",
month = "1",
day = "1",
doi = "10.1038/s41562-019-0659-6",
language = "English",
journal = "Nature Human Behaviour",
issn = "2397-3374",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Shared vulnerability for connectome alterations across psychiatric and neurological brain disorders

AU - Alzheimer’s Disease Neuroimaging Initiative

AU - de Lange, Siemon C.

AU - Scholtens, Lianne H.

AU - van den Berg, Leonard H.

AU - Boks, Marco P.

AU - Bozzali, Marco

AU - Cahn, Wiepke

AU - Dannlowski, Udo

AU - Durston, Sarah

AU - Geuze, Elbert

AU - van Haren, Neeltje E.M.

AU - Hillegers, Manon H.J.

AU - Koch, Kathrin

AU - Jurado, María Ángeles

AU - Mancini, Matteo

AU - Marqués-Iturria, Idoia

AU - Meinert, Susanne

AU - Ophoff, Roel A.

AU - Reess, Tim J.

AU - Repple, Jonathan

AU - Kahn, René S.

AU - van den Heuvel, Martijn P.

PY - 2019/1/1

Y1 - 2019/1/1

N2 - Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.

AB - Macroscale white matter pathways are the infrastructure for large-scale communication in the human brain and a prerequisite for healthy brain function. Disruptions in the brain’s connectivity architecture play an important role in many psychiatric and neurological brain disorders. Here we show that connections important for global communication and network integration are particularly vulnerable to brain alterations across multiple brain disorders. We report on a cross-disorder connectome study comprising in total 1,033 patients and 1,154 matched controls across 8 psychiatric and 4 neurological disorders. We extracted disorder connectome fingerprints for each of these 12 disorders and combined them into a ‘cross-disorder disconnectivity involvement map’ describing the level of cross-disorder involvement of each white matter pathway of the human brain network. Network analysis revealed connections central to global network communication and integration to display high disturbance across disorders, suggesting a general cross-disorder involvement and the importance of these pathways in normal function.

UR - http://www.scopus.com/inward/record.url?scp=85070236674&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85070236674&partnerID=8YFLogxK

U2 - 10.1038/s41562-019-0659-6

DO - 10.1038/s41562-019-0659-6

M3 - Article

JO - Nature Human Behaviour

JF - Nature Human Behaviour

SN - 2397-3374

ER -