Sharing at the major histocompatibility complex affects the secondary sex ratio in differing ways

Paola Astolfi; Mariaclara Cuccia; Calogero Caruso; Biagio Favoino; Marianna Fazzari; Vilma Mantovani; Patrizia Lulli; Mariateresa Illeni; Miryam Martinetti

Sharing at the major histocompatibility complex affects the secondary sex ratio in differing ways

Paola Astolfi, Mariaclara Cuccia, Calogero Caruso, Biagio Favoino, Marianna Fazzari, Vilma Mantovani, Patrizia Lulli, Mariateresa Illeni, Miryam Martinetti

IRCCS Fondazione Policlinico San Matteo

Research output: Contribution to journal › Article › peer-review

Abstract

We analysed the effect of HLA loci on the secondary sex ratio, and investigated whether allele sharing between parents and between mother and child, or child homozygosity, affected the viability of male embryos, which are generally less resistant to unfavourable conditions during pregnancy. The sharing conditions at the B and DR loci showed significantly differing effects: HLA-B seemed to favour female births, while, in pregnancies subsequent to the first, HLA-DR seemed to favour male births. Both HLA-B and DR loci seemed to work through immunological mechanisms.

Original language	English
Pages (from-to)	155-165
Number of pages	11
Journal	Human Heredity
Volume	46
Issue number	3
Publication status	Published - May 1996

Keywords

Fertility
HLA sharing
HLA-DR
Human sex ratio
Mother-child histocompatibility

ASJC Scopus subject areas

Genetics(clinical)

Cite this

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title = "Sharing at the major histocompatibility complex affects the secondary sex ratio in differing ways",

abstract = "We analysed the effect of HLA loci on the secondary sex ratio, and investigated whether allele sharing between parents and between mother and child, or child homozygosity, affected the viability of male embryos, which are generally less resistant to unfavourable conditions during pregnancy. The sharing conditions at the B and DR loci showed significantly differing effects: HLA-B seemed to favour female births, while, in pregnancies subsequent to the first, HLA-DR seemed to favour male births. Both HLA-B and DR loci seemed to work through immunological mechanisms.",

keywords = "Fertility, HLA sharing, HLA-DR, Human sex ratio, Mother-child histocompatibility",

author = "Paola Astolfi and Mariaclara Cuccia and Calogero Caruso and Biagio Favoino and Marianna Fazzari and Vilma Mantovani and Patrizia Lulli and Mariateresa Illeni and Miryam Martinetti",

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AU - Astolfi, Paola

AU - Cuccia, Mariaclara

AU - Caruso, Calogero

AU - Favoino, Biagio

AU - Fazzari, Marianna

AU - Mantovani, Vilma

AU - Lulli, Patrizia

AU - Illeni, Mariateresa

AU - Martinetti, Miryam

PY - 1996/5

Y1 - 1996/5

N2 - We analysed the effect of HLA loci on the secondary sex ratio, and investigated whether allele sharing between parents and between mother and child, or child homozygosity, affected the viability of male embryos, which are generally less resistant to unfavourable conditions during pregnancy. The sharing conditions at the B and DR loci showed significantly differing effects: HLA-B seemed to favour female births, while, in pregnancies subsequent to the first, HLA-DR seemed to favour male births. Both HLA-B and DR loci seemed to work through immunological mechanisms.

AB - We analysed the effect of HLA loci on the secondary sex ratio, and investigated whether allele sharing between parents and between mother and child, or child homozygosity, affected the viability of male embryos, which are generally less resistant to unfavourable conditions during pregnancy. The sharing conditions at the B and DR loci showed significantly differing effects: HLA-B seemed to favour female births, while, in pregnancies subsequent to the first, HLA-DR seemed to favour male births. Both HLA-B and DR loci seemed to work through immunological mechanisms.

KW - Fertility

KW - HLA sharing

KW - HLA-DR

KW - Human sex ratio

KW - Mother-child histocompatibility

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Sharing at the major histocompatibility complex affects the secondary sex ratio in differing ways

Abstract

Keywords

ASJC Scopus subject areas

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