Abstract
We analysed the effect of HLA loci on the secondary sex ratio, and investigated whether allele sharing between parents and between mother and child, or child homozygosity, affected the viability of male embryos, which are generally less resistant to unfavourable conditions during pregnancy. The sharing conditions at the B and DR loci showed significantly differing effects: HLA-B seemed to favour female births, while, in pregnancies subsequent to the first, HLA-DR seemed to favour male births. Both HLA-B and DR loci seemed to work through immunological mechanisms.
| Original language | English |
|---|---|
| Pages (from-to) | 155-165 |
| Number of pages | 11 |
| Journal | Human Heredity |
| Volume | 46 |
| Issue number | 3 |
| Publication status | Published - May 1996 |
Keywords
- Fertility
- HLA sharing
- HLA-DR
- Human sex ratio
- Mother-child histocompatibility
ASJC Scopus subject areas
- Genetics(clinical)
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Astolfi, P., Cuccia, M., Caruso, C., Favoino, B., Fazzari, M., Mantovani, V., Lulli, P., Illeni, M., & Martinetti, M. (1996). Sharing at the major histocompatibility complex affects the secondary sex ratio in differing ways. Human Heredity, 46(3), 155-165.