Shedding new light on female fertility: The role of vitamin D

Giovanna Muscogiuri, Barbara Altieri, Cristina de Angelis, Stefano Palomba, Rosario Pivonello, Annamaria Colao, Francesco Orio

Research output: Contribution to journalArticle

  • 5 Citations

Abstract

In the last decades several studies suggested that vitamin D is involved in the modulation of the reproductive process in women due to the expression of VDR and 1α-hydroxylase in reproductive tissues such as ovary, uterus, placenta, pituitary and hypothalamus. Vitamin D has also a role in the regulation of sex hormone steroidogenesis. Increasing evidence suggests that vitamin D might have a regulatory role in polycystic ovary syndrome (PCOS)-associated symptoms, including ovulatory dysfunction, insulin resistance and hyperandrogenism. Vitamin D deficiency also has been reported to contribute to the pathogenesis of endometriosis due to its immunomodulatory and anti-inflammatory properties. Although most of the studies supported a role of vitamin D in the onset of these diseases, randomized controlled trials to assess the efficacy of vitamin D supplementation have never been performed. In this review we critically discuss the role of vitamin D in female fertility, starting from in vitro and in vivo studies, focusing our attention on the two most frequent causes of female infertility: PCOS and endometriosis.

Original languageEnglish
Pages (from-to)1-11
Number of pages11
JournalReviews in Endocrine and Metabolic Disorders
DOIs
StateAccepted/In press - Jan 19 2017

Fingerprint

Vitamin D
Fertility
Polycystic Ovary Syndrome
Endometriosis
Female Infertility
Hyperandrogenism
Vitamin D Deficiency
Gonadal Steroid Hormones
Mixed Function Oxygenases
Placenta
Hypothalamus
Uterus
Insulin Resistance
Ovary
Anti-Inflammatory Agents
Randomized Controlled Trials
In Vitro Techniques

Keywords

  • Endometriosis
  • Female fertility
  • PCOS
  • Vitamin D

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Muscogiuri, G., Altieri, B., de Angelis, C., Palomba, S., Pivonello, R., Colao, A., & Orio, F. (2017). Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders, 1-11. DOI: 10.1007/s11154-017-9407-2

Shedding new light on female fertility : The role of vitamin D. / Muscogiuri, Giovanna; Altieri, Barbara; de Angelis, Cristina; Palomba, Stefano; Pivonello, Rosario; Colao, Annamaria; Orio, Francesco.

In: Reviews in Endocrine and Metabolic Disorders, 19.01.2017, p. 1-11.

Research output: Contribution to journalArticle

Muscogiuri, G, Altieri, B, de Angelis, C, Palomba, S, Pivonello, R, Colao, A & Orio, F 2017, 'Shedding new light on female fertility: The role of vitamin D' Reviews in Endocrine and Metabolic Disorders, pp. 1-11. DOI: 10.1007/s11154-017-9407-2
Muscogiuri G, Altieri B, de Angelis C, Palomba S, Pivonello R, Colao A et al. Shedding new light on female fertility: The role of vitamin D. Reviews in Endocrine and Metabolic Disorders. 2017 Jan 19;1-11. Available from, DOI: 10.1007/s11154-017-9407-2

Muscogiuri, Giovanna; Altieri, Barbara; de Angelis, Cristina; Palomba, Stefano; Pivonello, Rosario; Colao, Annamaria; Orio, Francesco / Shedding new light on female fertility : The role of vitamin D.

In: Reviews in Endocrine and Metabolic Disorders, 19.01.2017, p. 1-11.

Research output: Contribution to journalArticle

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