Shedding of membrane vesicles by tumor and endothelial cells

V. Dolo, S. D'Ascenzo, I. Giusti, D. Millimaggi, G. Taraboletti, A. Pavan

Research output: Contribution to journalArticlepeer-review


Shedding of membrane vesicles is a vital phenomenon frequently observed in tumor cells and suggested to be involved in several aspects of tumor progression. Our previous studies have shown that human breast tumor cells rapidly shed membrane vesicles containing matrix metalloproteinases (MMPs). In this study we present that human umbilical vein endothelial cells (HUVEC) as well as different tumor cell lines (human ovarian cancer, CABA I and A2780, and hepatocarcinoma cell line, SK-Hep 1) shed vesicles in the extracellular medium. These vesicles carry MMPs and their inhibitors TIMPs. We conclude that tumor and endothelial cells shed MMP-containing vesicles and this may represent a mechanism for regulating focalized proteolytic activity and a way to interact with microenvironment during tumor angiogenesis.

Original languageEnglish
Pages (from-to)127-133
Number of pages7
JournalItalian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia
Issue number2 SUPPL. 1
Publication statusPublished - 2005


  • Angiogenesis
  • Endothelial cells
  • Membrane vesicles
  • Shedding
  • Tumor

ASJC Scopus subject areas

  • Medicine(all)


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