Shifting from constant-voltage to constant-current in Parkinson’s disease patients with chronic stimulation

P. Amami, M. M. Mascia, A. Franzini, F. Saba, A. Albanese

Research output: Contribution to journalArticle

Abstract

The study aimed to evaluate safety and efficacy of shifting stimulation settings from constant-voltage (CV) to constant-current (CC) programming in patients with Parkinson’s disease (PD) and chronic subthalamic nucleus deep brain stimulation (STN DBS). Twenty PD patients with chronic STN DBS set in CV programming were shifted to CC and followed for 3 months; the other stimulation settings and the medication regimen remained unchanged. Side effects, motor, non-motor, executive functions, and impedance were assessed at baseline and during follow-up. No adverse events were observed at time of shifting or during CC stimulation. Motor and non-motor measures remained unchanged at follow-up despite impedance decreased. Compared to baseline, inhibition processes improved at follow-up. The shifting strategy was well tolerated and the clinical outcome was maintained with no need to adjust stimulation settings or medications notwithstanding a decrease of impedance. Improvement of inhibition processes is a finding which needed further investigation.

Original languageEnglish
Pages (from-to)1505-1508
Number of pages4
JournalNeurological Sciences
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

Keywords

  • Constant current
  • Deep brain stimulation
  • Executive functions
  • Parkinson’s disease
  • Subthalamic nucleus

ASJC Scopus subject areas

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

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