Shiga toxin-associated hemolytic uremic syndrome: Pathophysiology of endothelial dysfunction

Carla Zoja, Simona Buelli, Marina Morigi

Research output: Contribution to journalArticlepeer-review

Abstract

Shiga toxin (Stx)-producing enterohemorrhagic Escherichia coli O157:H7 has become a global threat to public health, as a primary cause of a worldwide spread of hemorrhagic colitis complicated by diarrhea-associated hemolytic uremic syndrome (HUS), a disorder of thrombocytopenia, microangiopathic hemolytic anemia, and acute renal failure that mainly affects early childhood. Endothelial dysfunction has been recognized as the trigger event in the development of microangiopathic processes. Endothelial cells, mainly those located in the renal microvasculature, are primary targets of the toxic effects of Stx1 and 2. Stxs bound to their specific globotriaosylceramide (Gb3Cer) receptor on the cell surface trigger a cascade of signaling events, involving NF-κB activation, that induce expression of genes encoding for adhesion molecules and chemokines, and culminate in the adhesion of leukocytes to endothelial cells, thereby increasing the endothelial susceptibility to leukocyte-mediated injury. Activated endothelial cells in response to Stxs lose the normal thromboresistance phenotype and become thrombogenic, initiating microvascular thrombus formation. Evidence is emerging that complement activation in response to Stxs favors platelet thrombus formation on endothelial cells, which may play a role in amplifying the inflammation-thrombosis circuit in Stx-associated HUS.

Original languageEnglish
Pages (from-to)2231-2240
Number of pages10
JournalPediatric Nephrology
Volume25
Issue number11
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Chemokines
  • Complement
  • Endothelial injury
  • Enterohemorrhagic Escherichia coli
  • Hemolytic uremic syndrome
  • Microvascular thrombosis
  • Shiga toxin

ASJC Scopus subject areas

  • Nephrology
  • Pediatrics, Perinatology, and Child Health

Fingerprint

Dive into the research topics of 'Shiga toxin-associated hemolytic uremic syndrome: Pathophysiology of endothelial dysfunction'. Together they form a unique fingerprint.

Cite this